Limitations in the ability to assemble large population-based cohorts of patients with systemic and/or cutaneous lupus with validated diagnoses and with significant representation from previously underrepresented socio-demographic groups have been a significant barrier to better understanding the true clinical burden of lupus, as well as the many unanswered questions related to treatment, health care access, and natural history. The Georgia Lupus Registry (GLR) is one of two recently completed Centers for Disease Control and Prevention-funded population-based lupus registries designed to minimize many of these limitations. The Georgians Organized Against Lupus (GOAL) Cohort was born out of the efforts of the GLR to create a population-based prospective cohort of validated and consented SLE patients, reflecting real world lupus in the community in and around Atlanta, Georgia. Since its inception, 802 lupus patients have been consented and finished enrollment in the first year (2011-2012) and a total of 929 SLE patients by the end of the second year (2013). It is also uniquely positioned to create the largest population-based cohort of cutaneous lupus in the US. Our proposal is completely responsive to all of the special eligibility requirements of thi FOA and will utilize the established GOAL Cohort to prospectively collect important information and biological materials to serve as a repository for hypothesis generation and investigation by qualified research groups. This powerful and unique collection of patients followed over time will also provide an opportunity to explore important areas that were not possible before. Our proposal will utilize an established population-based lupus cohort to prospectively collect important information and biological materials to serve as a repository for hypothesis generation and investigation by qualified research groups. This powerful and unique collection of patients followed over time will also provide an opportunity to explore important areas that were not possible before. Specifically, we propose 2 projects that will explore how important and innovative components of social determinants of health interact with clinical, socioeconomic, and/or biologic factors to influence cardiovascular disease outcomes in systemic lupus erythematosus and quality of life in cutaneous lupus erythematosus as a way of understanding and addressing the significant racial health disparities that continue to exist. A third project wil use innovative laboratory platforms to test our ability to better predict those who are at highest risk of disease flares, potentially further mitigating disparities in the burden of disease. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

Public Health Relevance

Lupus is a complex autoimmune disease that disproportionately afflicts women, particularly from minority groups. Significant racial health disparities remain and may be getting worse. Investigation into areas that will reduce these disparities is important for our population's health and will inform us about how best to treat everyone with this condition. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

Agency
National Institute of Health (NIH)
Institute
National Center for Chronic Disease Prev and Health Promo (NCCDPHP)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DP005119-03
Application #
9112787
Study Section
Special Emphasis Panel (ZDP1)
Program Officer
Shaw, Susan
Project Start
2014-09-01
Project End
2019-08-31
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
3
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Plantinga, Laura; Tift, Benjamin D; Dunlop-Thomas, Charmayne et al. (2018) Geriatric Assessment of Physical and Cognitive Functioning in a Diverse Cohort of Systemic Lupus Erythematosus Patients: A Pilot Study. Arthritis Care Res (Hoboken) 70:1469-1477
Plantinga, L; Lim, S S; Bowling, C B et al. (2017) Perceived stress and reported cognitive symptoms among Georgia patients with systemic lupus erythematosus. Lupus 26:1064-1071
Plantinga, Laura; Lim, S Sam; Patzer, Rachel et al. (2016) Incidence of End-Stage Renal Disease Among Newly Diagnosed Systemic Lupus Erythematosus Patients: The Georgia Lupus Registry. Arthritis Care Res (Hoboken) 68:357-65
Knight, Jessica H; Howards, Penelope P; Spencer, Jessica B et al. (2016) Characteristics related to early secondary amenorrhoea and pregnancy among women diagnosed with systemic lupus erythematosus: an analysis using the GOAL study. Lupus Sci Med 3:e000139
Plantinga, Laura; Lim, S Sam; Bowling, C Barrett et al. (2016) Association of age with health-related quality of life in a cohort of patients with systemic lupus erythematosus: the Georgians Organized Against Lupus study. Lupus Sci Med 3:e000161
Plantinga, Laura C; Lim, S Sam; Patzer, Rachel E et al. (2016) Comparison of vascular access outcomes in patients with end-stage renal disease attributed to systemic lupus erythematosus vs. other causes: a retrospective cohort study. BMC Nephrol 17:64
Plantinga, Laura C; Drenkard, Cristina; Pastan, Stephen O et al. (2016) Attribution of cause of end-stage renal disease among patients with systemic lupus erythematosus: the Georgia Lupus Registry. Lupus Sci Med 3:e000132
Plantinga, Laura C; Patzer, Rachel E; Drenkard, Cristina et al. (2015) Comparison of quality-of-care measures in U.S. patients with end-stage renal disease secondary to lupus nephritis vs. other causes. BMC Nephrol 16:39
Plantinga, Laura C; Drenkard, Cristina; Patzer, Rachel E et al. (2015) Sociodemographic and geographic predictors of quality of care in United States patients with end-stage renal disease due to lupus nephritis. Arthritis Rheumatol 67:761-72