This proposal undertakes to design and implement the Pharmacogenetics Network (CGN) database. The sub-objectives include: 1. Read-only access to a subset of the database schema for the research community, and read-write access of most of the schema to members of the Network. 2. Incorporation of security measures to limit unauthorized access, and means of protecting subject confidentiality. 3. In addition to the needs of end- users who will primarily browse the data, we will also provide an interface geared to the needs of data analysts and data miners. This interface will provide ad hoc query and bulk data extraction facilities. Creation of the database will involve integration and porting from other Internet-accessible databases that the investigators have previously built to address the management of clinical data, gene characterization data and biospecimen inventory. The database will be accessible over the World-Wide-through a standard browser. Input of data into the system will come primarily through periodic bulk import of data that is maintained locally at individual nodes in the CGN. Informatics assistance will be provided to the individual nodes to assist the task of data exchange, and when necessary, to assist the design of local data collection systems.
| Brandt, Cynthia A; Argraves, Stephanie; Money, Roy et al. (2006) Informatics tools to improve clinical research study implementation. Contemp Clin Trials 27:112-22 |
| Nadkarni, P M; Brandt, C A (2006) The Common Data Elements for cancer research: remarks on functions and structure. Methods Inf Med 45:594-601 |
| Nadkarni, Prakash M; Wiepert, Mathieu (2005) Translating pharmacogenomics discoveries into clinical practice: the role of curated databases. Pharmacogenomics 6:451-4 |
| Holford, Matthew; Li, Naixin; Nadkarni, Prakash et al. (2005) VitaPad: visualization tools for the analysis of pathway data. Bioinformatics 21:1596-602 |
| Brandt, Cynthia A; Gadagkar, Rohit; Rodriguez, Cesar et al. (2004) Managing complex change in clinical study metadata. J Am Med Inform Assoc 11:380-91 |
| Marenco, Luis; Wang, Tzuu-Yi; Shepherd, Gordon et al. (2004) QIS: A framework for biomedical database federation. J Am Med Inform Assoc 11:523-34 |
| Marenco, Luis; Tosches, Nicholas; Crasto, Chiquito et al. (2003) Achieving evolvable Web-database bioscience applications using the EAV/CR framework: recent advances. J Am Med Inform Assoc 10:444-53 |
| Nadkarni, P M (2003) The challenges of recording phenotype in a generalizable and computable form. Pharmacogenomics J 3:8-10 |
| Fisk, John M; Mutalik, Pradeep; Levin, Forrest W et al. (2003) Integrating query of relational and textual data in clinical databases: a case study. J Am Med Inform Assoc 10:21-38 |
| Nadkarni, P M (2002) An introduction to information retrieval: applications in genomics. Pharmacogenomics J 2:96-102 |
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