The ability to quickly and reliably detect chemical toxicants in air is critically important for health risk assessment, for better understanding the role of gene-environment interactions in human diseases, and for health disparities research. Current detection of chemical toxicants relies on bulky and expensive spectroscopic and chromatographic techniques that require considerable maintenance and operator expertise, which are not practical for continuously monitoring various chemicals at multiple locations. Many portable devices have been proposed and developed, but they have different limitations ranging from low selectivity, insufficient sensitivity, limited scope and high costs. The present project brings together a joint effort involving chemical sensor researchers at Arizona State University (ASU), toxicologist at University of Arizona (UA), R&D scientists and engineers at Motorola and field testing experts at Arizona Division of Occupational Safety &Health (ADOSH) to build, validate and test a powerful wearable sensing system. The sensor technology is built upon a novel microfabricated tuning fork array sensor platform invented at ASU and wireless sensor technology developed at Motorola. The project will leverage on the expertise and resources gathered for an on-going collaborative R&D effort on wireless chemical sensors between the ASU and Motorola team. The goal is not only a wearable sensor system for quick, accurate and reliable detection of chemical toxicants, but also an affordable, easy-to-upgrade and user friendly product for population studies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01ES016064-04S1
Application #
8121768
Study Section
Special Emphasis Panel (ZES1-RAM-D (U1))
Program Officer
Balshaw, David M
Project Start
2007-08-15
Project End
2013-05-31
Budget Start
2010-06-01
Budget End
2013-05-31
Support Year
4
Fiscal Year
2010
Total Cost
$231,781
Indirect Cost
Name
Arizona State University-Tempe Campus
Department
Type
DUNS #
943360412
City
Tempe
State
AZ
Country
United States
Zip Code
85287
Deng, Yue; Liu, Nai-Yuan; Tsow, Francis et al. (2017) Adsorption Thermodynamic Analysis of a Quartz Tuning Fork Based Sensor for Volatile Organic Compounds Detection. ACS Sens 2:1662-1668
Deng, Yue; Chen, Cheng; Xian, Xiaojun et al. (2016) A Novel Wireless Wearable Volatile Organic Compound (VOC) Monitoring Device with Disposable Sensors. Sensors (Basel) 16:
Chen, Cheng; Tsow, Francis; Xian, Xiaojun et al. (2015) A wearable sensing system for assessment of exposures to environmental volatile organic compounds. Methods Mol Biol 1256:201-11
Chen, Cheng; Tsow, Francis; Campbell, Katherine Driggs et al. (2013) A wireless hybrid chemical sensor for detection of environmental volatile organic compounds. IEEE Sens J 13:1748-1755
Chen, Cheng; Campbell, Katherine Driggs; Negi, Indira et al. (2012) A New Sensor for the Assessment of Personal Exposure to Volatile Organic Compounds. Atmos Environ 54:679-687
Negi, Indira; Tsow, Francis; Tanwar, Kshitiz et al. (2011) Novel monitor paradigm for real-time exposure assessment. J Expo Sci Environ Epidemiol 21:419-26
Zhang, Lihua; Tsow, Francis; Forzani, Erica et al. (2010) Reversible oxygen gas sensor based on electrochemiluminescence. Chem Commun (Camb) 46:3333-5
Prabhakar, Amlendu; Iglesias, Rodrigo A; Wang, Rui et al. (2010) Ultrasensitive detection of nitrogen oxides over a nanoporous membrane. Anal Chem 82:9938-40
Wang, Rui; Tsow, Francis; Zhang, Xuezhi et al. (2009) Real-time ozone detection based on a microfabricated quartz crystal tuning fork sensor. Sensors (Basel) 9:5655-63
Iglesias, Rodrigo A; Tsow, Francis; Wang, Rui et al. (2009) Hybrid separation and detection device for analysis of benzene, toluene, ethylbenzene, and xylenes in complex samples. Anal Chem 81:8930-5

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