Title: Male Circumcision for HIV Prevention in Kenya: Seeking effective strategies to recruit older menBackground: In Kenya, 1.4-1.6 million people are living with HIV, with an adult prevalence of6.3%. Nyanza, one of the eight provinces, has the highest prevalence, at 13.9%. Within Nyanza,HIV prevalence in the districts occupied by the Luo - the dominant ethnic community in theprovince and third nationally - was 20.2% (17.1% in men and 22.8% in women). Several driversof the rapid spread of HIV in the province have been identified as, among other factors, lack ofmale circumcision. A large number of observational studies and three randomized controlledtrials concurred in their findings, that male circumcision reduces the risk of acquiring HIV byabout 60%. Following the publications of these results and subsequent endorsement by theWorld Health Organization, Kenya rolled out male circumcision (MC) services from October2008, and by March 2011, had circumcised 250,807 people in Nyanza province, 115,196 of theseperformed by our organization. However, uptake of services by older men (aged >25 years) whoare more at risk of acquiring HIV has been elusive. We propose to evaluate different strategies torecruit men aged 25-39 years - Inter-Personal Communication (IPC), Conditional Cash Transfer(CCT), and a combination of IPC and CCT - in terms of uptake and cost of MC in Nyanza.Goal and Aims: With a goal of getting 80% of men aged 25-39 years circumcised, the specificaims are to: i) assess the rate of uptake of MC services among four categories of men aged 25-39years: those exposed CCT vs. those exposed to IPC vs. those exposed to both interventionscombined vs. those receiving no intervention; ii) determine the cost of providing MC among thethree interventions vs. no intervention; iii) determine, through anonymous testing blood from theexcised foreskin, the proportion of men who decline pre-operative testing who are HIV infected;and iv) link 80% of those who test positive in MC settings to HIV care and treatment programs.Methods: Three recruitment approaches will be implemented and evaluated: IPC, CCT and acombination of the two. Under IPC, we will engage those who have been circumcised, femalechampions, work-place champions, and opinion leaders to conduct one-on-one and small-grouprecruitment and referrals to our MC service sites; Under CCT, spouses or adult family memberswill accompany clients for MC services and couple HTC and MC education will be offered toclients with spouses. After surgery, the spouse/family member will be given a food stamp worthKShs. 1,750 (USD 23) per day for one week. The stamp will be presented to a designated shop inexchange of food stuff for use by the family when the bread-winner is recovering; UnderCombined IPC and CCT, the effect of both interventions implemented together will beexamined; In the Control District, no intervention will be implemented. The proposed study isunique in several ways: given MC is a one-off intervention, using cash incentives to increase theuptake of the services would pay off in terms of achieving faster population level impact;utilizing local resources and existing community structures to promote public health will ensuresustainability; and cash transfer to the spouse will promote women's involvement in decision-making around circumcision of their spouses. We anticipate doubling, in one year, the number ofmen age 25-39 years circumcised over the last 21/2 years, from 10,519 to 21,038, with acontributory ratio of 1:1.5:2 by IPC, CCT and IPC/CCT interventions, respectively.

Public Health Relevance

Over two and a half years into rolling out male circumcision for HIV prevention in Kenya, less than 10% of those circumcised to date (n=250,807) are in the critical age (25-39 years) that would translate into a more immediate impact on population-level HIV incidence. The proposed evaluation study will identify effective approaches to getting older men to take up male circumcision services in order to realize the impact of the intervention sooner than would otherwise be the case if the current trend of circumcising under 24-year-olds continue.

Agency
National Institute of Health (NIH)
Institute
Coordinating Office of Global Health (COGH)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01GH000518-01
Application #
8261782
Study Section
Special Emphasis Panel (ZGH1-SRC (99))
Project Start
2012-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
1
Fiscal Year
2012
Total Cost
$500,000
Indirect Cost
Name
Impact Research and Development Org
Department
Type
DUNS #
360303965
City
Kisumu
State
Country
Kenya
Zip Code
40100