Abstract

Public Health Relevance

Advanced mass spectrometry methods with structure determinafions will allow for improved understandng of the interactions between human host proteins and pathogens;this research may lead to new therapies for infecfious diseases. The specific pathogen model to be studied here is Salmonella, a pathogen that has been the cause of a number of significant food-bourne outbreaks in recent years.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01GM094623-01
Application #
8152480
Study Section
Special Emphasis Panel (ZGM1-CBB-0 (BC))
Project Start
2010-09-30
Project End
2015-06-30
Budget Start
2010-09-30
Budget End
2011-06-30
Support Year
1
Fiscal Year
2010
Total Cost
$1,161,252
Indirect Cost

  Institution

Name
Battelle Pacific Northwest Laboratories
Department
Type
DUNS #
032987476
City
Richland
State
WA
Country
United States
Zip Code
99352

  Publications

Wu, Jikang; Sabag-Daigle, Anice; Borton, Mikayla A et al. (2018) Salmonella-Mediated Inflammation Eliminates Competitors for Fructose-Asparagine in the Gut. Infect Immun 86:
Merkley, Eric D; Sego, Landon H; Lin, Andy et al. (2017) Protein abundances can distinguish between naturally-occurring and laboratory strains of Yersinia pestis, the causative agent of plague. PLoS One 12:e0183478
Waters, Elaine M; Rudkin, Justine K; Coughlan, Simone et al. (2017) Redeploying ?-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections. J Infect Dis 215:80-87
Lama, Amrita; Drennan, Samuel L; Johnson, Rudd C et al. (2017) Identification of Conserved ABC Importers Necessary for Intracellular Survival of Legionella pneumophila in Multiple Hosts. Front Cell Infect Microbiol 7:485
Negretti, Nicholas M; Gourley, Christopher R; Clair, Geremy et al. (2017) The food-borne pathogen Campylobacter jejuni responds to the bile salt deoxycholate with countermeasures to reactive oxygen species. Sci Rep 7:15455
Sontag, Ryan L; Nakayasu, Ernesto S; Brown, Roslyn N et al. (2016) Identification of Novel Host Interactors of Effectors Secreted by Salmonella and Citrobacter. mSystems 1:
Nakayasu, Ernesto S; Sydor, Michael A; Brown, Roslyn N et al. (2015) Identification of Salmonella Typhimurium Deubiquitinase SseL Substrates by Immunoaffinity Enrichment and Quantitative Proteomic Analysis. J Proteome Res 14:4029-38
Sontag, Ryan L; Mihai, Cosmin; Orr, Galya et al. (2015) Electroporation of functional bacterial effectors into mammalian cells. J Vis Exp :52296
Elfenbein, Johanna R; Knodler, Leigh A; Nakayasu, Ernesto S et al. (2015) Multicopy Single-Stranded DNA Directs Intestinal Colonization of Enteric Pathogens. PLoS Genet 11:e1005472
Li, Jie; Overall, Christopher C; Nakayasu, Ernesto S et al. (2015) Analysis of the Salmonella regulatory network suggests involvement of SsrB and H-NS in ?(E)-regulated SPI-2 gene expression. Front Microbiol 6:27

Showing the most recent 10 out of 24 publications