Abstract

Description) The investigators propose to examine further the roles of Prostaglandins (PGs) catalyzed by cyclooxygenases (COX-1 and COX-2) during various phases of uterine receptivity using mice mutated for the COX-1 or COX-2 gene. They also plan to examine whether leukotrienes (LTs) alone or with PGs play any roles in implantation.
The specific aims are to examine: (1) the expression of COX-1 and COX-2, and levels of PGs in the periimplantation uteri of wild-type, heterozygous or homozygous mice mutated for the COX-2 and COX-1 genes, respectively, (2) the expression of PG receptors, and (3) of (COX) 5-lipoxygenase (5-LO) and levels of LTs in the periimplantation uteri of these mice, as well as (4) role of PGs/LTs in the attainment of uterine receptivity for implantation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HD029968-08
Application #
6125700
Study Section
Special Emphasis Panel (SRC (18))
Program Officer
Tasca, Richard J
Project Start
1992-12-01
Project End
2001-11-30
Budget Start
1999-12-01
Budget End
2001-11-30
Support Year
8
Fiscal Year
2000
Total Cost
$274,742
Indirect Cost

  Institution

Name
University of Kansas
Department
Physiology
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160

  Publications

Wang, Haibin; Dey, Sudhansu K (2005) Lipid signaling in embryo implantation. Prostaglandins Other Lipid Mediat 77:84-102
Dey, S K; Lim, H; Das, Sanjoy K et al. (2004) Molecular cues to implantation. Endocr Rev 25:341-73
Song, Haengseok; Lim, Hyunjung; Paria, Bibhash C et al. (2002) Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development. Development 129:2879-89
Paria, B C; Reese, Jeff; Das, Sanjoy K et al. (2002) Deciphering the cross-talk of implantation: advances and challenges. Science 296:2185-8
Lim, Hyunjung; Song, Haengseok; Paria, B C et al. (2002) Molecules in blastocyst implantation: uterine and embryonic perspectives. Vitam Horm 64:43-76
Tan, Jian; Raja, Shefali; Davis, Marilyn K et al. (2002) Evidence for coordinated interaction of cyclin D3 with p21 and cdk6 in directing the development of uterine stromal cell decidualization and polyploidy during implantation. Mech Dev 111:99-113
Lim, Hyunjung; Dey, Sudhansu K (2002) A novel pathway of prostacyclin signaling-hanging out with nuclear receptors. Endocrinology 143:3207-10
Matsumoto, Hiromichi; Ma, Wen-Ge; Daikoku, Takiko et al. (2002) Cyclooxygenase-2 differentially directs uterine angiogenesis during implantation in mice. J Biol Chem 277:29260-7
Matsumoto, Hiromichi; Zhao, Xuemei; Das, Sanjoy K et al. (2002) Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus. Dev Biol 245:280-90
Paria, B C; Ma, W; Tan, J et al. (2001) Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. Proc Natl Acad Sci U S A 98:1047-52

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