This is an application for the re-competition of the Adolescent Medicine Trials Unit in San Francisco, a collaboration between the University of California San Francisco (UCSF) and Larkin Street Youth services (LSYS). San Francisco targets the key vulnerable populations outlined in the RFA: runaway homeless, substance abusing and minority youth, as well as transgender youth.
Our aims remain to continue outreach to vulnerable youth both HIV infected and uninfected at risk and to engage them safely in clinical and behavioral research.
We aim to continue creating a strong infrastructure for performing HIV vaccine trials in the future. We believe we contributed to the overall strength and breadth of the ATM and meet the expectations for renewal. Our site is an ATU centered in the community rather than the university; bringing university expertise in partnership to the community. Our primary clinical population of HIV positive youth receives medical care at Larkin Street Youth Services' (LSYS) community clinic, and we now have engaged more than 14 other community sites in recruitment and referrals into ATN studies. As of March 1, 2005 we have recruited 77 subjects into currently open clinical and prevention protocols at our site (021,022, 023B,024, 025, and 0168), have participated in several protocol development teams (015, 016B, 034, 039 and PACTG 1046), and a member of our staff was lead author on the first paper to be completed about Connect to Protect. UCSF Division of Adolescent Medicine is a rich resource for adolescent medicine research and clinical services to youth. The ATU at SF team includes the PI, Dr. Moscicki, our Connect to Protect (C2P)team members Catherine Geanuracos, LCSW, Kevin Sniecinski, and Dr. Colette Auerswald, Study Coordinators Bethany Certa, RN, BSN and J.B. Molaghan ANP-C, and staff assistant Nigel Reyes. At LSYS, Alan Taggart, M.D., has served HIV infected and uninfected youth at Larkin Street Youth for over nine years. He and Heather Weisbrod, the outreach worker, have effectively identified, screened and recruited homeless youth into trials. Our clinic services include LSYS, which has a comprehensive, youth centered, culturally appropriate model of HIV care, and, at UCSF, the Positive Health Practices and Pediatrics AIDS Program. In summary, our ATU site is a unique partnership between the university and the community. During the last 5 years, we have solidified our commitment to ensure marginalized and vulnerable youths' right to participate in research. The Connect to Protect project has expanded our involvement with the community and has brought additional agencies into our referral network. We believe it is critical to continue to engage the high risk youth in the San Francisco Bay Area in clinical and behavioral research. ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01HD040506-06
Application #
7049907
Study Section
Special Emphasis Panel (ZHD1-DRG-D (25))
Program Officer
Ryan, Kevin W
Project Start
2001-04-16
Project End
2011-02-28
Budget Start
2006-03-01
Budget End
2007-02-28
Support Year
6
Fiscal Year
2006
Total Cost
$374,113
Indirect Cost
Name
University of California San Francisco
Department
Pediatrics
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Bangi, Audrey; Dolcini, M Margaret; Harper, Gary W et al. (2013) Psychosocial Outcomes of Sexual Risk Reduction in a Brief Intervention for Urban African American Female Adolescents. J HIV AIDS Soc Serv 12:146-159
Doll, Mimi; Harper, Gary W; Robles-Schrader, Grisel M et al. (2012) Perspectives of community partners and researchers about factors impacting coalition functioning over time. J Prev Interv Community 40:87-102
Robles-Schrader, Grisel M; Harper, Gary W; Purnell, Marjorie et al. (2012) Differential challenges in coalition building among HIV prevention coalitions targeting specific youth populations. J Prev Interv Community 40:131-48
Willard, Nancy; Chutuape, Kate; Stines, Stephanie et al. (2012) Bridging the gap between individual-level risk for HIV and structural determinants: using root cause analysis in strategic planning. J Prev Interv Community 40:103-17
Lin, Alison J; Dudek, Julia C; Francisco, Vincent T et al. (2012) Challenges and approaches to mobilizing communities for HIV prevention among young men who have sex with men of color. J Prev Interv Community 40:149-64
Reed, Sarah J; Miller, Robin Lin; Francisco, Vincent T et al. (2012) Programmatic capacity and HIV structural change interventions: influences on coalitions' success and efficiency in accomplishing intermediate outcomes. J Prev Interv Community 40:118-30
Sill, Anne M; Constantine, Niel T; Wilson, Craig M et al. (2010) Demographic profiles of newly acquired HIV infections among adolescents and young adults in the U.S. J Adolesc Health 46:93-6
Dolcini, M Margaret; Harper, Gary W; Boyer, Cherrie B et al. (2010) Project ORE: A friendship-based intervention to prevent HIV/STI in urban African American adolescent females. Health Educ Behav 37:115-32
Jennings, Jacky M; Ellen, Jonathan M; Deeds, Bethany Griffin et al. (2009) Youth living with HIV and partner-specific risk for the secondary transmission of HIV. Sex Transm Dis 36:439-44
Deeds, Bethany Griffin; Peralta, Ligia; Willard, Nancy et al. (2008) The role of community resource assessments in the development of 15 adolescent health community-researcher partnerships. Prog Community Health Partnersh 2:31-9

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