The Bogalusa Heart Study is a long-term, epidemiologic program concerned with the early natural history of arteriosclerosis (atherosclerosis and essential hypertension) in a total biracial (black- white)childhood population, now reaching 20-41 years of age. The proposed research focuses on physiologic, genetic and lifestyle factors that contribute to cardiovascular (C-V)disease.
The specific aims of the proposal are to study: 1) the impact of genetic factors on the evolution from childhood C-V risk factors to subclinical (C- V structural and functional characteristics) and clinical morbidity in adult population followed over a long period of time; and 2) the association of risk factor phenotypes to anatomic changes in the C- V system as seen by necropsy. The population for genotype- phenotype studies include approximately 1,400 siblings (sibships greater than 2) derived from 17 longitudinal birth cohorts. The C- V phenotypes include obesity measures, blood pressures, lipids, lipoproteins and apoproteins, homocysteine, glucose-insulin, fibrinogen, plasminogen activator inhibitor-1 and von Willebrand factor. The environmental risk factors consist of sociodemographic characteristics, tobacco and alcohol use, oral contraception, physical activity and diet. Subclinical morbidity will include echo-Doppler measurements of cardiac-carotid structure and function. Using robust sibling pair linkage methods, a genome-wide searching involving 391 markers with spacing of 10cM will be conducted for genes which influence quantitative traits. This will be supplemented with 41 highly polymorphic markers located in or near candidate genes likely to be related to obesity, lipoprotein metabolism, blood pressure levels, insulin resistance, diabetes, atherogenesis and thrombosis. Emphasis will be placed on longitudinal changes of clustering of correlated traits, i.e., insulin- resistant syndrome, Syndrome X. Analyses will be conducted to assess whether the same genes exert significant effects in both blacks and whites. Autopsy studies will address relationship of antemortem risk factors with the development of anatomic atherosclerotic and hypertensive lesions. The proposed studies will enable development of rational prevention programs.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project--Cooperative Agreements (U01)
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Special Emphasis Panel (ZHL1-CSR-G (M2))
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Tulane University
Social Sciences
Schools of Arts and Sciences
New Orleans
United States
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Bhuiyan, Azad R; Srinivasan, Sathanur R; Chen, Wei et al. (2015) Timing of menarche related to carotid artery intima-media thickness in black and white young adult women: the Bogalusa Heart Study. Ann Epidemiol 25:414-9
Dwyer, Terence; Sun, Cong; Magnussen, Costan G et al. (2013) Cohort Profile: the international childhood cardiovascular cohort (i3C) consortium. Int J Epidemiol 42:86-96
Berenson, Gerald S; Bogalusa Heart Study group (2012) Health consequences of obesity. Pediatr Blood Cancer 58:117-21
Harville, Emily W; Srinivasan, Sathanur; Chen, Wei et al. (2012) Is the metabolic syndrome a ""small baby"" syndrome?: the bogalusa heart study. Metab Syndr Relat Disord 10:413-21
Juonala, Markus; Magnussen, Costan G; Berenson, Gerald S et al. (2011) Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med 365:1876-85
Toprak, Demet; Toprak, Ahmet; Chen, Wei et al. (2011) Adiposity in childhood is related to C-reactive protein and adiponectin in young adulthood: from the Bogalusa Heart Study. Obesity (Silver Spring) 19:185-90
Dasmahapatra, Pronabesh; Srinivasan, Sathanur R; Mokha, Jasmeet et al. (2011) Subclinical atherosclerotic changes related to chronic kidney disease in asymptomatic black and white young adults: the Bogalusa heart study. Ann Epidemiol 21:311-7
Chio, Shiu-Shin; Urbina, Elaine M; Lapointe, Jeffery et al. (2011) Korotkoff sound versus oscillometric cuff sphygmomanometers: comparison between auscultatory and DynaPulse blood pressure measurements. J Am Soc Hypertens 5:12-20
Toprak, Ahmet; Kandavar, Ramprasad; Toprak, Demet et al. (2011) C-reactive protein is an independent predictor for carotid artery intima-media thickness progression in asymptomatic younger adults (from the Bogalusa Heart Study). BMC Cardiovasc Disord 11:78
Camhi, Sarah M; Katzmarzyk, Peter T; Broyles, Stephanie et al. (2010) Predicting adult body mass index-specific metabolic risk from childhood. Metab Syndr Relat Disord 8:165-72

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