Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL045692-05
Application #
2222387
Study Section
Clinical Trials Review Committee (CLTR)
Project Start
1991-05-17
Project End
1998-04-30
Budget Start
1995-05-19
Budget End
1998-04-30
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Ballas, Samir K; Connes, Philippe; Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia (2018) Rheological properties of sickle erythrocytes in patients with sickle-cell anemia: The effect of hydroxyurea, fetal hemoglobin, and ?-thalassemia. Eur J Haematol 101:798-803
Ballas, Samir K; Barton, Franca B; Waclawiw, Myron A et al. (2006) Hydroxyurea and sickle cell anemia: effect on quality of life. Health Qual Life Outcomes 4:59
Moore, R D; Charache, S; Terrin, M L et al. (2000) Cost-effectiveness of hydroxyurea in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. Am J Hematol 64:26-31
Ballas, S K; Marcolina, M J; Dover, G J et al. (1999) Erythropoietic activity in patients with sickle cell anaemia before and after treatment with hydroxyurea. Br J Haematol 105:491-6
Li, J; Plonczynski, M; Steinberg, M H et al. (1998) Severe Hb S-beta+ thalassemia caused by IVS-I splice site mutations. Hemoglobin 22:383-6
Steinberg, M H; Lu, Z H; Nagel, R L et al. (1998) Hematological effects of atypical and Cameroon beta-globin gene haplotypes in adult sickle cell anemia. Am J Hematol 59:121-6
Figueiredo, M S; Steinberg, M H (1997) Fetal hemoglobin in sickle cell anemia: examination of phylogenetically conserved sequences within the locus control region but outside the cores of hypersensitive sites 2 and 3. Blood Cells Mol Dis 23:188-200
McMahon, R P; Waclawiw, M A; Geller, N L et al. (1997) An extension of stochastic curtailment for incompletely reported and classified recurrent events: the Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH). Control Clin Trials 18:420-30
Steinberg, M H; Lu, Z H; Barton, F B et al. (1997) Fetal hemoglobin in sickle cell anemia: determinants of response to hydroxyurea. Multicenter Study of Hydroxyurea. Blood 89:1078-88
Hackney, A C; Hezier, W; Gulledge, T P et al. (1997) Effects of hydroxyurea administration on the body weight, body composition and exercise performance of patients with sickle-cell anaemia. Clin Sci (Lond) 92:481-6

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