Investigators from the Cardiovascular Health Study Coordinating Center at the University of Washington propose to establish a Coordinating Center (CC) which will participate with the Field Centers and the National Heart, Lung, and Blood Institute (NHLBI) in conducting a study of the cardiovascular consequences of sleep apnea and other sleep-related breathing disorders (SRBD). The CC will subcontract with Case Western Reserve University to provide expertise in the study of sleep disorders and to establish a Sleep Reading Center for the central processing of all data on sleep apnea and other SRBD. The primary objective of the study is to determine the degree to which SRBD are risk factors for the development of cardiovascular and cerebrovascular disease, as well as to examine possible associations with other cardiovascular risk factors. We will also investigate the degree to which SRBD affect prognosis in individuals with sub-clinical or clinical cardiovascular disease. The study will use existing, well-characterized population-based cohorts as participants in this study. The Coordinating Center will provide biostatistical expertise, data management, reporting services, data analysis, and overall study coordination and management. The Coordinating Center will collate and analyze data collected in parent studies for comparability across studies, and will collect, edit, store, and analyze data generated by the Field Centers for the study of SRBD. The Coordinating Center investigators will collaborate with other investigators in analyzing the study data for presentation and publication.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CCT-R (S1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
Biostatistics & Other Math Sci
Schools of Public Health
United States
Zip Code
Ho, Vu; Crainiceanu, Ciprian M; Punjabi, Naresh M et al. (2015) Calibration Model for Apnea-Hypopnea Indices: Impact of Alternative Criteria for Hypopneas. Sleep 38:1887-92
Roca, Gabriela Querejeta; Redline, Susan; Claggett, Brian et al. (2015) Sex-Specific Association of Sleep Apnea Severity With Subclinical Myocardial Injury, Ventricular Hypertrophy, and Heart Failure Risk in a Community-Dwelling Cohort: The Atherosclerosis Risk in Communities-Sleep Heart Health Study. Circulation 132:1329-37
Chami, Hassan A; Gottlieb, Daniel J; Redline, Susan et al. (2015) Association between Glucose Metabolism and Sleep-disordered Breathing during REM Sleep. Am J Respir Crit Care Med 192:1118-26
Querejeta Roca, Gabriela; Redline, Susan; Punjabi, Naresh et al. (2013) Sleep apnea is associated with subclinical myocardial injury in the community. The ARIC-SHHS study. Am J Respir Crit Care Med 188:1460-5
Chami, Hassan A; Fontes, João D; Vasan, Ramachandran S et al. (2013) Vascular inflammation and sleep disordered breathing in a community-based cohort. Sleep 36:763-768C
Parthasarathy, Sairam; Fitzgerald, MaryPat; Goodwin, James L et al. (2012) Nocturia, sleep-disordered breathing, and cardiovascular morbidity in a community-based cohort. PLoS One 7:e30969
Budhiraja, Pooja; Budhiraja, Rohit; Goodwin, James L et al. (2012) Incidence of restless legs syndrome and its correlates. J Clin Sleep Med 8:119-24
Silva, Graciela E; Vana, Kimberly D; Goodwin, James L et al. (2011) Identification of patients with sleep disordered breathing: comparing the four-variable screening tool, STOP, STOP-Bang, and Epworth Sleepiness Scales. J Clin Sleep Med 7:467-72
Bruce, E N; Bruce, M C; Ramanand, P et al. (2011) Progressive changes in cortical state before and after spontaneous arousals from sleep in elderly and middle-aged women. Neuroscience 175:184-97
Chami, Hassan A; Resnick, Helaine E; Quan, Stuart F et al. (2011) Association of incident cardiovascular disease with progression of sleep-disordered breathing. Circulation 123:1280-6

Showing the most recent 10 out of 72 publications