? ? The Family Blood Pressure Program [FBPP] is an unprecedented collaboration to identify genes influencing blood pressure levels, hypertension and its cardiovascular complications (hereafter referred to as """"""""hypertension genes""""""""). To date, the Program has carried out 21,600 physical examinations, assembled a shared database of 294 hypertension-relevant variables, measured quantitative echocardiograms on 7,321 individuals, carried-out genome-wide linkage analyses for hypertension status and 13 related phenotypes, published (or in press) 128 manuscripts and identified 5 hypertension susceptibility genes by following-up 4 linkage peaks. In the proposed next phase of the FBPP, a major emphasis is placed on making the Program a shared resource for hypertension researchers in the United States and throughout the world.
In Aim 1, we will build, maintain and update a publicly available knowledge-base to facilitate research by non-FBPP investigators on the genetics of hypertension, its risk factors and its complications.
In Aim 2, we will use state-of-the-art genetic linkage analysis methods to identify additional linkage regions using subgroups of pedigrees and physiologically relevant combinations of phenotypes that will aid in localizing hypertension genes.
In Aim 3, we will use a combination of bioinformatics, a dense array of SNPs, and state-of-the-art ? data analysis to follow-up regions of interest and identify the underlying hypertension genes. The regions to be followed-up include those identified during the current phase of the FBPP and Aim 2 of this renewal phase.
In Aim 4, we will evaluate the hypertension genes identified in Aim 3 for their association with multiple measures reflecting the cardiovascular and renal complications of hypertension, including left ventricular mass and microalbuminuria. It is the long-term goal of the FBPP to have the hypertension genetics community develop a comprehensive picture of the genetic architecture of human hypertension, including its risk factors, complications, and response to treatment. ? (End of Abstract) ? ?
| Nandakumar, Priyanka; Lee, Dongwon; Richard, Melissa A et al. (2017) Rare coding variants associated with blood pressure variation in 15?914 individuals of African ancestry. J Hypertens 35:1381-1389 |
| Weissgerber, Tracey L; Turner, Stephen T; Mosley Jr, Thomas H et al. (2016) Hypertension in Pregnancy and Future Cardiovascular Event Risk in Siblings. J Am Soc Nephrol 27:894-902 |
| Scantlebury, Dawn C; Kane, Garvan C; Wiste, Heather J et al. (2015) Left ventricular hypertrophy after hypertensive pregnancy disorders. Heart 101:1584-90 |
| Weissgerber, Tracey L; Milic, Natasa M; Turner, Stephen T et al. (2015) Uric Acid: A Missing Link Between Hypertensive Pregnancy Disorders and Future Cardiovascular Disease? Mayo Clin Proc 90:1207-16 |
| Simino, Jeannette; Kume, Rezart; Kraja, Aldi T et al. (2014) Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program. Atherosclerosis 235:84-93 |
| Brown, Catherine M; Turner, Stephen T; Bailey, Kent R et al. (2013) Hypertension in pregnancy is associated with elevated C-reactive protein levels later in life. J Hypertens 31:2213-9; discussion 2219 |
| Weissgerber, Tracey L; Turner, Stephen T; Bailey, Kent R et al. (2013) Hypertension in pregnancy is a risk factor for peripheral arterial disease decades after pregnancy. Atherosclerosis 229:212-6 |
| White, Wendy M; Turner, Stephen T; Bailey, Kent R et al. (2013) Hypertension in pregnancy is associated with elevated homocysteine levels later in life. Am J Obstet Gynecol 209:454.e1-7 |
| Monda, Keri L; Chen, Gary K; Taylor, Kira C et al. (2013) A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet 45:690-6 |
| Kattah, Andrea G; Asad, Reem; Scantlebury, Dawn C et al. (2013) Hypertension in pregnancy is a risk factor for microalbuminuria later in life. J Clin Hypertens (Greenwich) 15:617-23 |
Showing the most recent 10 out of 20 publications
