This coordinating center application is part of a set of applications from five participating institutions. PREMIER, a randomized clinical trial, will determine how two multi-component lifestyle interventions affect blood pressure (BP). Although numerous organizations recommend lifestyle change to control BP and potentially prevent hypertension, practical implementation strategies have yet to be developed and tested. The two lifestyle interventions to be tested in PREMIER include a """"""""comprehensive"""""""" intervention implementing current recommendations for BP control (reduced salt intake; increased physical activity; moderation of alcohol intake; and weight loss, if appropriate), and a """"""""comprehensive plus DASH"""""""" intervention implementing current recommendations plus the Dietary Approaches to Stop Hypertension (DASH) dietary pattern (rich in fruits, vegetables, and low fat dairy products, and reduced in saturated fat, total fat, and cholesterol). These lifestyle intervention programs will consist of a series of group and individual counseling sessions similar in intensity to health education programs currently provided by health care delivery systems for other conditions. Study participants (n=800) will be 25 years of age or older, with systolic BP of 120-159 mmHg and diastolic BP of 80-95 mmHg. Approximately half of the participants will be female, 40 percent will be African American, and 30 percent will have stage 1 hypertension. After three screening visits, participants will be randomly assigned to one of the two lifestyle interventions or a usual care control group. Follow-up will last 18 months after randomization. The primary outcome will be systolic BP with diastolic BP as a secondary outcome. Additional outcome variables will include fasting lipids, fasting glucose, insulin, and homocysteine. The trial hypotheses will be examined in all participants as well as separately in non hypertensive and hypertensive subgroups. Results from PREMIER will provide the scientific rationale for routinely implementing comprehensive lifestyle intervention programs to control BP and ultimately prevent BP-related cardiovascular disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL060573-03
Application #
6184519
Study Section
Special Emphasis Panel (ZHL1-CSR-L (M2))
Project Start
1998-09-01
Project End
2003-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
3
Fiscal Year
2000
Total Cost
$904,128
Indirect Cost
Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
City
Oakland
State
CA
Country
United States
Zip Code
94612
Jerome, G J; Myers, V H; Young, D R et al. (2015) Psychosocial predictors of weight loss by race and sex. Clin Obes 5:342-8
Crist, Laura A; Champagne, Catherine M; Corsino, Leonor et al. (2012) Influence of change in aerobic fitness and weight on prevalence of metabolic syndrome. Prev Chronic Dis 9:E68
Lin, Pao-Hwa; Wang, Yanfang; Grambow, Steven C et al. (2012) Dietary saturated fat intake is negatively associated with weight maintenance among the PREMIER participants. Obesity (Silver Spring) 20:571-5
Bartfield, Jessica K; Stevens, Victor J; Jerome, Gerald J et al. (2011) Behavioral transitions and weight change patterns within the PREMIER trial. Obesity (Silver Spring) 19:1609-15
Kennedy, Betty M; Kumanyika, Shiriki; Ard, Jamy D et al. (2010) Overall and minority-focused recruitment strategies in the PREMIER multicenter trial of lifestyle interventions for blood pressure control. Contemp Clin Trials 31:49-54
Lin, Pao-Hwa; Miwa, Saki; Li, Yi-Ju et al. (2010) Factors influencing dietary protein sources in the PREMIER trial population. J Am Diet Assoc 110:291-5
Young, Deborah Rohm; Coughlin, Janelle; Jerome, Gerald J et al. (2010) Effects of the PREMIER interventions on health-related quality of life. Ann Behav Med 40:302-12
Chen, Liwei; Caballero, Benjamin; Mitchell, Diane C et al. (2010) Reducing consumption of sugar-sweetened beverages is associated with reduced blood pressure: a prospective study among United States adults. Circulation 121:2398-406
Maruthur, Nisa M; Wang, Nae-Yuh; Appel, Lawrence J (2009) Lifestyle interventions reduce coronary heart disease risk: results from the PREMIER Trial. Circulation 119:2026-31
Young, Deborah Rohm; Vollmer, William M; King, Abby C et al. (2009) Can individuals meet multiple physical activity and dietary behavior goals? Am J Health Behav 33:277-86

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