This R01 application is submitted in support of a PGA entitled """"""""Expression Profiling of Rodent Models of Human Disease."""""""" The theme is this application is Examining Gene/Environment Interactions in Rodent Models of Human Disease Using cDNA Microarrays to link phenotype to genotype. In support of that application, we will: 1. Establish an Administration and Coordination Component to oversee the PGA and coordinate its scientific activities. 2. Establish a Mouse cDNA Microarray Development and Analysis Component that will develop a Gene Index Mouse cDNA collection, assemble mouse microarrays, and use those arrays to measure tissue- specific patterns of gene expression in mouse models of human heart, lung, blood, and sleep disorders.
| Tseveleki, Vivian; Rubio, Renee; Vamvakas, Sotiris-Spyros et al. (2010) Comparative gene expression analysis in mouse models for multiple sclerosis, Alzheimer's disease and stroke for identifying commonly regulated and disease-specific gene changes. Genomics 96:82-91 |
| Antonescu, Corina; Antonescu, Valentin; Sultana, Razvan et al. (2010) Using the DFCI gene index databases for biological discovery. Curr Protoc Bioinformatics Chapter 1:Unit1.6.1-36 |
| Kitami, Toshimori; Rubio, Renee; O'Brien, William et al. (2008) Gene-environment interactions reveal a homeostatic role for cholesterol metabolism during dietary folate perturbation in mice. Physiol Genomics 35:182-90 |
| Walker, Julia K L; Ahumada, Adriana; Frank, Bryan et al. (2006) Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness. Am J Respir Cell Mol Biol 34:711-8 |
| Cook, Donald N; Whitehead, Gregory S; Burch, Lauranell H et al. (2006) Spontaneous mutations in recombinant inbred mice: mutant toll-like receptor 4 (Tlr4) in BXD29 mice. Genetics 172:1751-5 |
| Bergman, Nicholas H; Passalacqua, Karla D; Gaspard, Renee et al. (2005) Murine macrophage transcriptional responses to Bacillus anthracis infection and intoxication. Infect Immun 73:1069-80 |
| Larkin, Jennie E; Frank, Bryan C; Gavras, Haralambos et al. (2005) Independence and reproducibility across microarray platforms. Nat Methods 2:337-44 |
| Sharov, Vasily; Kwong, Ka Yin; Frank, Bryan et al. (2004) The limits of log-ratios. BMC Biotechnol 4:3 |
| Larkin, Jennie E; Frank, Bryan C; Gaspard, Renee M et al. (2004) Cardiac transcriptional response to acute and chronic angiotensin II treatments. Physiol Genomics 18:152-66 |
| Cook, Donald N; Wang, Shuibang; Wang, Yonghong et al. (2004) Genetic regulation of endotoxin-induced airway disease. Genomics 83:961-9 |
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