Overweight/obesity is the second leading cause of death in the US, and is growing in prevalence at an alarming rate. Control of overweight/obesity is increasingly recognized as a high national priority because of its contribution to cardiovascular (CVD) risk factors and ultimately to CVD itself. The short-term success of behavioral interventions for weight loss has been repeatedly documented. Unfortunately, because weight re-gain is extremely common, a disappointingly, small proportion of individuals achieve long-term weight control. Of the factors that are associated with sustained weight loss, one of the most important is continued intervention with frequent contacts. We propose a multi-center, randomized, controlled trial [Weight Loss Maintenance Trial (MAINTENANCE)] to determine the effects of two innovative behavioral interventions, each designed to maintain frequent contacts, compared to a usual care control group. Overweight and obese individuals (approximately 60% women, approximately 40% African Americans) who are taking medication for hypertension, dyslipidemia and/or type 2 diabetes will enter a 6-month, weight loss program. Those individuals who lose at least 4 kg (N = 800) will then be randomized into one of three groups: a Personal Contact (PC) Intervention that provides monthly personal contacts with a trained interventionist, primarily via telephone; an Interactive Technology (IT) Intervention that provides frequent contacts through a state-of-the-art interactive web-based program supplemented by other communication technologies; or Usual Care (UC). The primary outcome will be weight change from the end of the initial weight loss program to the end of the 30-month weight maintenance intervention period. Other outcomes will include weight change in subgroups, prevalence of CVD risk factors, measures of behavior change, and cost of implementation. For each outcome, the PC and IT interventions will be compared to UC and, if different from UC, to each other. To successfully combat the obesity epidemic, clinicians and health care systems must have options that are effective and feasible and that can be provided to large numbers of individuals. The purpose of this proposal is to develop and test two such interventions, which, if effective, should complement ongoing efforts to stem the obesity epidemic and ultimately prevent obesity-related CVD.
| Shantavasinkul, Prapimporn Chattranukulchai; Muehlbauer, Michael J; Bain, James R et al. (2018) Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid. Surg Obes Relat Dis 14:1126-1132 |
| Fitzpatrick, Stephanie L; Appel, Lawrence J; Bray, Bethany et al. (2018) Predictors of Long-Term Adherence to Multiple Health Behavior Recommendations for Weight Management. Health Educ Behav 45:997-1007 |
| Coughlin, Janelle W; Brantley, Phillip J; Champagne, Catherine M et al. (2016) The impact of continued intervention on weight: Five-year results from the weight loss maintenance trial. Obesity (Silver Spring) 24:1046-53 |
| Brantley, Phillip J; Stewart, Diana W; Myers, Valerie H et al. (2014) Psychosocial predictors of weight regain in the weight loss maintenance trial. J Behav Med 37:1155-68 |
| Mcvay, Megan A; Myers, Valerie H; Vollmer, William M et al. (2014) Predictors of dietary change among those who successfully lost weight in phase I of the Weight Loss Maintenance Trial. Nutr Diet 71:144-151 |
| Svetkey, Laura P; Clark, Jeanne M; Funk, Kristine et al. (2014) Greater weight loss with increasing age in the weight loss maintenance trial. Obesity (Silver Spring) 22:39-44 |
| Tyson, Crystal C; Appel, Lawrence J; Vollmer, William M et al. (2013) Impact of 5-year weight change on blood pressure: results from the Weight Loss Maintenance trial. J Clin Hypertens (Greenwich) 15:458-64 |
| Coughlin, J W; Gullion, C M; Brantley, P J et al. (2013) Behavioral mediators of treatment effects in the weight loss maintenance trial. Ann Behav Med 46:369-81 |
| Myers, Valerie H; McVay, Megan A; Champagne, Catherine M et al. (2013) Weight loss history as a predictor of weight loss: results from Phase I of the weight loss maintenance trial. J Behav Med 36:574-82 |
| Patel, Mahesh J; Batch, Bryan C; Svetkey, Laura P et al. (2013) Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults. OMICS 17:627-35 |
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