This project is part of a Blood and Marrow Transplant Clinical Research Network which is conducting multicenter clinical trials in hematopoietic stem cell transplantation. The purpose of the network is to promote the efficient comparison of novel treatment methods and management strategies of potential benefit for children and adults undergoing blood or marrow transplantation. Studies under development include a comparison of blood versus marrow stem cell transplantation. Studies under development include a comparison of blood versus marrow stem cell transplantation after marrow ablation, the development of non-myeloablative transplant regimens, and the best ways to avoid infections in transplant patients.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL069348-03
Application #
6667137
Study Section
Special Emphasis Panel (ZHL1-CSR-F (S1))
Program Officer
Henslee-Downey, Jean
Project Start
2001-09-30
Project End
2006-08-31
Budget Start
2003-09-09
Budget End
2004-08-31
Support Year
3
Fiscal Year
2003
Total Cost
$389,323
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Spagnol, Stephen T; Lin, Wei-Chun; Booth, Elizabeth A et al. (2016) Early Passage Dependence of Mesenchymal Stem Cell Mechanics Influences Cellular Invasion and Migration. Ann Biomed Eng 44:2123-31
Devine, Steven M; Carter, Shelly; Soiffer, Robert J et al. (2011) Low risk of chronic graft-versus-host disease and relapse associated with T cell-depleted peripheral blood stem cell transplantation for acute myelogenous leukemia in first remission: results of the blood and marrow transplant clinical trials network prot Biol Blood Marrow Transplant 17:1343-51
Caimi, Paolo F; Reese, Jane; Lee, Zhenghong et al. (2010) Emerging therapeutic approaches for multipotent mesenchymal stromal cells. Curr Opin Hematol 17:505-13
Arfons, Lisa M; Tomblyn, Marcie; Rocha, Vanderson et al. (2009) Second hematopoietic stem cell transplantation in myeloid malignancies. Curr Opin Hematol 16:112-23