Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL070525-04
Application #
6786757
Study Section
Special Emphasis Panel (ZDK1-GRB-4 (O2))
Program Officer
Rabadan-Diehl, Cristina
Project Start
2001-09-30
Project End
2006-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
4
Fiscal Year
2004
Total Cost
$736,888
Indirect Cost
Name
University of Utah
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Noh, Junghyun; Wende, Adam R; Olsen, Curtis D et al. (2015) Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations. J Mol Cell Cardiol 89:297-305
Ilkun, Olesya; Wilde, Nicole; Tuinei, Joseph et al. (2015) Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome. J Mol Cell Cardiol 85:104-16
Wende, Adam R; O'Neill, Brian T; Bugger, Heiko et al. (2015) Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes. Mol Cell Biol 35:831-46
Li, Yan; Wende, Adam R; Nunthakungwan, Orathai et al. (2012) Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice. FEBS J 279:599-611
Bugger, Heiko; Riehle, Christian; Jaishy, Bharat et al. (2012) Genetic loss of insulin receptors worsens cardiac efficiency in diabetes. J Mol Cell Cardiol 52:1019-26
Abel, E Dale; Sweeney, Gary (2012) Modulation of the cardiovascular system by leptin. Biochimie 94:2097-103
Sloan, Crystal; Tuinei, Joseph; Nemetz, Katherine et al. (2011) Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric-restricted ob/ob mice. Diabetes 60:1424-34
Bugger, Heiko; Abel, E Dale (2010) Mitochondria in the diabetic heart. Cardiovasc Res 88:229-40
Wende, Adam R; Abel, E Dale (2010) Lipotoxicity in the heart. Biochim Biophys Acta 1801:311-9
Sena, Sandra; Hu, Ping; Zhang, Dongfang et al. (2009) Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction. J Mol Cell Cardiol 46:910-8

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