Over the past decade there has been a heightened awareness of the disproportionate impact of asthma morbidity and mortality among African Americans and persons of lower social economic status. The causes underlying this disparity have not been fully elucidated. However, there is strong evidence that the level of social stress imposed by this condition and the degree of coping and self-management skills present are factors that may be particularly important in explaining these disparities. The purpose of this project is to develop a collaborative research program between Northwestern University Feinberg School of Medicine and Cook County Hospital to fully characterize the relationship of social stress, coping, and self-regulatory health behaviors in the context of asthma disparities among African American and low income populations. Once characterized, the project will then develop and test an intervention strategy to reduce asthma disparities in high-risk populations based on evidence-based models that have demonstrated success in social work, nursing, and community interventions. There are four research aims for this proposed Center of Excellence. (1) To develop and validate culturally appropriate psychosocial instruments related to the underlying causes of disparity in asthma morbidity (2) To identify the structural relationships of psychosocial factors to other known influential factors related to disparities in asthma outcomes. (3) To study the changes in structural relationship among influential factors in asthma disparity over time as related to changes in health status. (4) To develop, pilot test, and field test a community-based asthma team (peer coach, asthma nurse, and social worker) intervention to enhance individuals ability to cope with chronic illness and improve asthma-related behaviors. A second major goal of this Center will be to train and mentor new clinical investigators and social scientists to be able to conduct research in this field of interest.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01HL072496-05S1
Application #
7668125
Study Section
Special Emphasis Panel (ZHL1-CSR-P (S2))
Program Officer
Taggart, Virginia
Project Start
2002-09-30
Project End
2009-07-31
Budget Start
2006-08-01
Budget End
2009-07-31
Support Year
5
Fiscal Year
2008
Total Cost
$68,000
Indirect Cost
Name
Hektoen Institute for Medical Research
Department
Type
DUNS #
068625136
City
Chicago
State
IL
Country
United States
Zip Code
60612
McCarville, Megan; Sohn, Min-Woong; Oh, Elissa et al. (2013) Environmental tobacco smoke and asthma exacerbations and severity: the difference between measured and reported exposure. Arch Dis Child 98:510-4
Martin, Molly A; Sadowski, Laura S; Moy, James N et al. (2011) Tobacco exposure and asthma morbidity in Puerto Ricans and Mexican Americans. Ann Allergy Asthma Immunol 106:346-8
Cho, Seong; Kang, Joseph; Lyttle, Christopher et al. (2011) Association of elevated plasminogen activator inhibitor 1 levels with diminished lung function in patients with asthma. Ann Allergy Asthma Immunol 106:371-7
Grammer, Leslie C; Weiss, Kevin B; Pedicano, Jennifer B et al. (2010) Obesity and asthma morbidity in a community-based adult cohort in a large urban area: the Chicago Initiative to Raise Asthma Health Equity (CHIRAH). J Asthma 47:491-5
Martin, Molly A; Catrambone, Catherine D; Kee, Romina A et al. (2009) Improving asthma self-efficacy: developing and testing a pilot community-based asthma intervention for African American adults. J Allergy Clin Immunol 123:153-159.e3
Weiss, Kevin B; Shannon, John Jay; Sadowski, Laura S et al. (2009) The burden of asthma in the Chicago community fifteen years after the availability of national asthma guidelines: the design and initial results from the CHIRAH study. Contemp Clin Trials 30:246-55
Evans, Arthur T; Sadowski, Laura S; VanderWeele, Tyler J et al. (2009) Ethnic disparities in asthma morbidity in Chicago. J Asthma 46:448-54
Kumar, Rajesh; Curtis, Laura Marie; Khiani, Sanjay et al. (2008) A community-based study of tobacco smoke exposure among inner-city children with asthma in Chicago. J Allergy Clin Immunol 122:754-759.e1
Mosnaim, Giselle S; Sadowski, Laura S; Durazo-Arvizu, Ramon A et al. (2007) Parental language and asthma among urban Hispanic children. J Allergy Clin Immunol 120:1160-5
Sharp, Lisa K; Kimmel, Linda G; Kee, Romina et al. (2007) Assessing the Perceived Stress Scale for African American adults with asthma and low literacy. J Asthma 44:311-6

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