This application is for the Toronto Hospital for Sick Children to participate in the Childhood Asthma Management Program Continuation Study/Phase 2 (CAMPCS/2). The abstract and research plan for CAMPCS/2 is included in the application from the Washington University (Robert Strunk, PI).
The specific aims of the projected study are the continued follow up and evaluation of this patient population through to adulthood, in order to better describe the impact of a. mild to moderate asthma on lung growth and airway remodelling asthma, and b. inhaled corticosteroids on eventual adult height. This is a long term observational study. The study population are children with mild to moderate asthma, originally enrolled in a placebo controlled trial of asthma therapy (the CAMP study). The Toronto CAMP Centre has been a participant in this multi-centred study since its inception in 1993 as the Childhood Asthma Management Program (CAMP). The Toronto CAMP clinic is committed to participate in CAMP/CS2 and supports the continued follow up of CAMP patients. We initially enrolled 125 patients in CAMP, and subsequently enrolled 109 patients in CAMPCS, with one subsequently re-enrolling. The families and patients participating in CAMPCS continue to be committed to the study and have expressed an interest in maintaining this relationship. We therefore anticipate their continued involvement through CAMPCS/2, and optimistic for 100% continued enrollment. There have been no changes in CAMPCS personnel (PI and nurse coordinators unchanged in 5 years), and they too remain committed to continuing this valuable study. We will therefore continue to collect data of high quality.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL075407-04
Application #
7096606
Study Section
Clinical Trials Review Committee (CLTR)
Program Officer
Taggart, Virginia
Project Start
2003-09-30
Project End
2007-09-29
Budget Start
2006-07-01
Budget End
2007-09-29
Support Year
4
Fiscal Year
2006
Total Cost
$182,327
Indirect Cost
Name
Hospital for Sick Chldrn (Toronto)
Department
Type
DUNS #
208511808
City
Toronto
State
ON
Country
Canada
Zip Code
M5 1-X8
McGeachie, Michael J; Yates, Katherine P; Zhou, Xiaobo et al. (2016) Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. Am J Respir Crit Care Med 194:1465-1474
Park, Heung-Woo; Song, Woo-Jung; Chang, Yoon-Suk et al. (2016) Bronchodilator response following methacholine-induced bronchoconstriction predicts acute asthma exacerbations. Eur Respir J 48:104-14
Strunk, Robert C; Colvin, Ryan; Bacharier, Leonard B et al. (2015) Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese. J Allergy Clin Immunol Pract 3:765-71.e2
Drye, Lea T; Casper, Anne S; Sternberg, Alice L et al. (2014) The transitioning from trials to extended follow-up studies. Clin Trials 11:635-47
Kelly, H William; Sternberg, Alice L; Lescher, Rachel et al. (2012) Effect of inhaled glucocorticoids in childhood on adult height. N Engl J Med 367:904-12
Wu, Ann Chen; Tantisira, Kelan; Li, Lingling et al. (2012) Effect of vitamin D and inhaled corticosteroid treatment on lung function in children. Am J Respir Crit Care Med 186:508-13
Wu, Ann Chen; Tantisira, Kelan; Li, Lingling et al. (2011) Predictors of symptoms are different from predictors of severe exacerbations from asthma in children. Chest 140:100-107
Raissy, Hengameh H; Sternberg, Alice L; Williams, Paul et al. (2010) Risk of cataracts in the Childhood Asthma Management Program Cohort. J Allergy Clin Immunol 126:389-92, 392.e1-4