This is an application for a Regional Clinical Center which will participate in a Clinical Research Consortium to improve resuscitation outcomes. The overall aim of the consortium is to conduct clinical research in primary cardiopulmonary arrest and in traumatic injury leading to or threatening cardiopulmonary collapse. In this application we address two areas where present resuscitation practices are inadequate: 1) establishing and securing an emergency airway during cardiopulmonary arrest and 2) treatment of traumatic brain injuries with hypotension. We propose two hypotheses which will be tested in randomized controlled clinical trials in prehospital cardiac arrest/head injuries: 1) a new emergency airway, the laryngeal tube airway, will be easier to insert successfully in prehospital cardiac arrest than the endotracheal tube, and will provide ventilatory capability equivalent to the endotracheal tube. 2) Intravenous administration of 7.5% (hypertonic) saline to patients with traumatic brain injuries and hypotension will result in lower intracranial pressures, improved initial Glasgow coma scores on arrival at the emergency department and improved survival with less neurologic damage. If our hypotheses are correct, the emergency treatment of cardiac arrest and traumatic brain injury patients will be significantly more effective, with fewer deaths and less long-term disability.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL077865-04
Application #
7276711
Study Section
Special Emphasis Panel (ZHL1-CSR-G (M1))
Program Officer
Sopko, George
Project Start
2004-09-01
Project End
2008-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
4
Fiscal Year
2007
Total Cost
$328,737
Indirect Cost
Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Pollack, Ross A; Brown, Siobhan P; Rea, Thomas et al. (2018) Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests. Circulation 137:2104-2113
Morrison, Laurie J; Schmicker, Robert H; Weisfeldt, Myron L et al. (2016) Effect of gender on outcome of out of hospital cardiac arrest in the Resuscitation Outcomes Consortium. Resuscitation 100:76-81
Rizoli, Sandro; Petersen, Ashley; Bulger, Eileen et al. (2016) Early prediction of outcome after severe traumatic brain injury: a simple and practical model. BMC Emerg Med 16:32
Salcido, David D; Torres, Cesar; Koller, Allison C et al. (2016) Regional incidence and outcome of out-of-hospital cardiac arrest associated with overdose. Resuscitation 99:13-9
Buick, Jason E; Ray, Joel G; Kiss, Alexander et al. (2016) The association between neighborhood effects and out-of-hospital cardiac arrest outcomes. Resuscitation 103:14-19
Sutton, Robert M; Case, Erin; Brown, Siobhan P et al. (2015) A quantitative analysis of out-of-hospital pediatric and adolescent resuscitation quality--A report from the ROC epistry-cardiac arrest. Resuscitation 93:150-7
Tisherman, Samuel A; Schmicker, Robert H; Brasel, Karen J et al. (2015) Detailed description of all deaths in both the shock and traumatic brain injury hypertonic saline trials of the Resuscitation Outcomes Consortium. Ann Surg 261:586-90
Buick, Jason E; Allan, Katherine S; Ray, Joel G et al. (2015) Does location matter? A proposed methodology to evaluate neighbourhood effects on cardiac arrest survival and bystander CPR. CJEM 17:286-94
Cheskes, Sheldon; Schmicker, Robert H; Rea, Tom et al. (2015) Chest compression fraction: A time dependent variable of survival in shockable out-of-hospital cardiac arrest. Resuscitation 97:129-35
Andrusiek, Douglas L; Szydlo, Danny; May, Susanne et al. (2015) A Comparison of Invasive Airway Management and Rates of Pneumonia in Prehospital and Hospital Settings. Prehosp Emerg Care 19:475-81

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