Young adults, age 20-35, experience the greatest rate of weight gain, averaging 1 to 2 pounds per year. This weight gain is associated with a worsening in cardiovascular risk factors and an increase in the prevalence of metabolic syndrome. Given the difficulties in producing sustained weight loss later in life, preventing weight gain from occurring during young adulthood is critical to curbing the obesity epidemic. This project involves two linked R01 applications--a Clinical Coordinating Center application submitted by Dr. Rena Wing, The Miriam Hospital, and a Data Coordinating Center, submitted by Dr. Mark Espeland, Wake Forest University School of Medicine. The purpose of the project is to test two interventions to prevent weight gain in young adults. Both interventions are based on a self-regulation approach that we have shown can help prevent weight regain in recent weight losers. Key aspects of this self-regulation include daily self-weighing, use of the information from the scale to know when adjustments in eating and activity are needed, behavioral skills to modify these behaviors, and small reinforcements for successful prevention of weight gain. One self-regulation intervention is focused on making small consistent changes in eating and exercise behavior to prevent weight gain;the other emphasizes periodic larger changes in eating and exercise behavior that result in small weight losses. These interventions will be compared to each other and to a control condition in a 3-armed randomized controlled clinical trial. The study will involve 600 adults (300 at the Miriam Hospital clinical site and 300 at the University of North Carolina clinical site), aged 18-35 with a BMI of 23-30, who are randomly assigned to 1) control;2) self-regulation intervention with small behavior changes or 3) self-regulation with large behavior changes. Participants will be recruited over 18 months and will be followed from randomization until the end of the grant, resulting in 24-48 months of follow-up (mean=3 years). The primary hypothesis is that the magnitude of weight gain across an average planned follow-up of 3 years will differ among the three groups (a priori hypothesis is that weight gain will be greatest in control, intermediate in small changes, and least in the large change condition). Secondary hypotheses will compare the three groups on the proportion gaining weight (defined as >1lb over baseline), changes in cardiovascular risk factors, and changes in the process measures (such as diet, physical activity, and dietary restraint). This project focuses on weight gain in young adults-a critical time for the prevention of obesity-and tests innovative approaches based on self-regulation of body eight. This approach shows promise for reducing weight gain and thereby improving long-term cardiovascular health.

Public Health Relevance

Weight gain in young adults is a major contributor to the epidemic of obesity and the increase in cardiovascular disease risk factors with age. Developing effective weight gain prevention interventions is an important public health priority. STOP (Study to Prevent) Weight Gain is a randomized clinical trial testing innovative interventions to prevent weight gain over an average 3 years of follow-up in individuals 18 to 35 years of age.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL090864-02
Application #
7918738
Study Section
Special Emphasis Panel (ZHL1-CSR-D (M1))
Program Officer
Loria, Catherine
Project Start
2009-08-18
Project End
2014-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
2
Fiscal Year
2010
Total Cost
$1,346,682
Indirect Cost
Name
Miriam Hospital
Department
Type
DUNS #
063902704
City
Providence
State
RI
Country
United States
Zip Code
02906
McCaffery, J M; Ordovas, J M; Huggins, G S et al. (2018) Weight gain prevention buffers the impact of CETP rs3764261 on high density lipoprotein cholesterol in young adulthood: The Study of Novel Approaches to Weight Gain Prevention (SNAP). Nutr Metab Cardiovasc Dis :
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Unick, Jessica L; Lang, Wei; Tate, Deborah F et al. (2017) Objective Estimates of Physical Activity and Sedentary Time among Young Adults. J Obes 2017:9257564
Wing, Rena R; Tate, Deborah F; Garcia, Katelyn R et al. (2017) Improvements in Cardiovascular Risk Factors in Young Adults in a Randomized Trial of Approaches to Weight Gain Prevention. Obesity (Silver Spring) 25:1660-1666
Tate, Deborah F; Lytle, Leslie A; Sherwood, Nancy E et al. (2016) Deconstructing interventions: approaches to studying behavior change techniques across obesity interventions. Transl Behav Med 6:236-43
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Crane, Melissa M; LaRose, Jessica Gokee; Espeland, Mark A et al. (2016) Recruitment of young adults for weight gain prevention: randomized comparison of direct mail strategies. Trials 17:282
Wing, Rena R; Tate, Deborah F; Espeland, Mark A et al. (2016) Innovative Self-Regulation Strategies to Reduce Weight Gain in Young Adults: The Study of Novel Approaches to Weight Gain Prevention (SNAP) Randomized Clinical Trial. JAMA Intern Med 176:755-62
Wing, Rena R; Tate, Deborah; LaRose, Jessica Gokee et al. (2015) Frequent self-weighing as part of a constellation of healthy weight control practices in young adults. Obesity (Silver Spring) 23:943-9
Tate, Deborah F; LaRose, Jessica G; Griffin, Leah P et al. (2014) Recruitment of young adults into a randomized controlled trial of weight gain prevention: message development, methods, and cost. Trials 15:326

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