The lymphatic system performs many crucial functions in health, gathering approximately 6 liters/day of interstitial fluid and returning it tothe venous system. As this fluid is filtered, undesirable elements such as tumor cells and foreign pathogens are normally destroyed in lymph nodes. This system is also part of the primary transport mechanism for the immune system. Lymphedema, a debilitating disease, for which there is no known cure, affects a large number of cancer patients who have undergone lymph node dissection, as well as trauma victims. The lymphatic system is also the major transport route for metastases of the most deadly cancers. Understanding and modeling the transport of lymph remains a challenge. Much of the pumping work comes from the contraction of lymphatic vessel smooth muscle, with valves preventing backflow. We are developing a multi-scale network model of the lymphatic circulation based on a combination of physical laws, material descriptions, and models of active cellular processes. Goals of this iterative model development process are to gain a better understanding of normal lymphatic function as well as multiple diseases.

Public Health Relevance

The lymphatic system is directly involved in Lymphedema, an incurable condition that affects a large percentage of cancer patients who have undergone surgery. It is also involved in the spread of cancer, serving as the principal route of distributio for cancer metastases.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project--Cooperative Agreements (U01)
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Special Emphasis Panel (ZEB1)
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Lee, Albert
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Texas A&M University
Schools of Medicine
College Station
United States
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Bertram, C D; Macaskill, C; Davis, M J et al. (2018) Contraction of collecting lymphatics: organization of pressure-dependent rate for multiple lymphangions. Biomech Model Mechanobiol 17:1513-1532
Narayanan, S Anand; Metzger, Corinne E; Bloomfield, Susan A et al. (2018) Inflammation-induced lymphatic architecture and bone turnover changes are ameliorated by irisin treatment in chronic inflammatory bowel disease. FASEB J 32:4848-4861
Clement, Cristina C; Wang, Wei; Dzieciatkowska, Monika et al. (2018) Quantitative Profiling of the Lymph Node Clearance Capacity. Sci Rep 8:11253
Moore Jr, James E; Brook, Bindi S; Nibbs, Robert J B (2018) Chemokine Transport Dynamics and Emerging Recognition of Their Role in Immune Function. Curr Opin Biomed Eng 5:90-95
Zawieja, Scott D; Castorena-Gonzalez, Jorge A; Scallan, Joshua P et al. (2018) Differences in L-type Ca2+ channel activity partially underlie the regional dichotomy in pumping behavior by murine peripheral and visceral lymphatic vessels. Am J Physiol Heart Circ Physiol 314:H991-H1010
Divan, Ali; Casselli, Timothy; Narayanan, S Anand et al. (2018) Borrelia burgdorferi adhere to blood vessels in the dura mater and are associated with increased meningeal T cells during murine disseminated borreliosis. PLoS One 13:e0196893
Moore Jr, James E; Bertram, Christopher D (2018) Lymphatic System Flows. Annu Rev Fluid Mech 50:459-482
Metzger, Corinne E; Narayanan, Anand; Zawieja, David C et al. (2017) Inflammatory Bowel Disease in a Rodent Model Alters Osteocyte Protein Levels Controlling Bone Turnover. J Bone Miner Res 32:802-813
Watson, Daniel J; Sazonov, Igor; Zawieja, David C et al. (2017) Integrated geometric and mechanical analysis of an image-based lymphatic valve. J Biomech 64:172-179
Zawieja, Scott D; Castorena-Gonzalez, Jorge A; Dixon, Brandon et al. (2017) Experimental Models Used to Assess Lymphatic Contractile Function. Lymphat Res Biol 15:331-342

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