The Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV Study (WIHS) Combined Cohort Study (CCS) is a large, comprehensive, prospective cohort study designed to investigate a spectrum of questions relating to the basic science, clinical science, and epidemiology of HIV infection in the US, with a focus on comorbidities among men and women living with HIV. The purpose of this application is to support the Data Analysis and Coordination Center (DACC) for the CCS.
The specific aims of the DACC are: 1) To optimize the contributions of the MACS and the WIHS to the understanding of the pathogenesis and treated history of HIV infection in U.S. adults by providing epidemiological and statistical expertise, and initiating and sustaining successful scientific partnerships, to support the unified science agenda; 2) To coordinate the recruitment of 2,500 new MACS/WIHS-CCS participants, including coordination of the administration of standardized baseline visits across all clinical research sites and integration of data from new recruits with the existing combined database; 3) To coordinate research initiatives and scientific presentations; to facilitate communication amongst CCS and external investigators, Working Groups and committees; to orchestrate study protocol and form revision; to coordinate outcome ascertainment and adjudication of clinical events; and to disseminate key scientific findings; 4) To develop and maintain a web-based data management system to harmonize and integrate data from the MACS and WIHS, as well as manage new data collected per the CCS protocol. We will continue our systems for: tracking the storage and transfer of biological specimens at national repositories, producing annual public data sets, and conducting training in methods that facilitate the appropriate use of study data for local research; and 5) To continue our quality assurance program in partnership with the clinical research sites that integrates expertise in data management, study coordination, statistical methodology, and scientific disciplines.

Public Health Relevance

This supplement will provide resources that expand our capacity of the MACS/WIHS-Clinical Cohort Study Data Analysis and Coordination Center capacity for new scientific initiatives. For each project, we will provide epidemiological and statistical expertise as collaborative scientific partners in study design and analysis; coordination effort for creating protocols, forms, and codebooks; and data management support and integration with our GEMINI data management system.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01HL146193-02S1
Application #
10133856
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Altekruse, Sean Fitzgerald
Project Start
2019-04-09
Project End
2026-03-31
Budget Start
2020-07-01
Budget End
2021-03-31
Support Year
2
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205