MACS/WIHS Combined Cohort Study (MWCCS) Administrative Supplement: Association of Alcohol Biomarkers with HIV and Clinical Outcomes Abstract. Fund Year 2020 OAR Strategic Funds are requested to perform an objective assessment of alcohol consumption in the MACS/WIHS Combined Cohort Study (MWCCS) by testing urine and blood specimens for ethyl glucuronide (EtG) and phosphatidylethanol (PEth), respectively. Specimens will be collected on existing MACS and WIHS participants who enroll into the MWCCS (n~4000) and in new MWCCS enrollees (n~1500) during CCS Visits 101 and 102 in order to better characterize alcohol use and their associations with HIV outcomes (i.e., antiretroviral therapy [ART] adherence, viral suppression down to a single copy) and clinical outcomes (i.e., liver, cardiac, neurocognitive impairment). This supplement will support HIV/AIDS research that falls under the following NIH high priority AIDS- designated topics: 1) HIV-associated comorbidities; and 2) cross-cutting areas including behavioral sciences, health disparities, and training of the next generation of HIV investigators in substance use and comorbidities research.

Public Health Relevance

An objective assessment of alcohol consumption in the MACS/WIHS Combined Cohort Study (MWCCS) by testing urine and blood specimens to be collected on existing MACS and WIHS participants who enroll into the MWCCS (n~4000) and in new MWCCS enrollees (n~1500) during CCS Visits 101 and 102 in order to better characterize alcohol use and their associations with HIV outcomes (i.e., antiretroviral therapy [ART] adherence, viral suppression down to a single copy) and clinical outcomes (i.e., liver, cardiac, neurocognitive impairment). This supplement will support HIV/AIDS research that falls under the following NIH high priority AIDS- designated topics: 1) HIV-associated comorbidities; and 2) cross-cutting areas including behavioral sciences, health disparities, and training of the next generation of HIV investigators in substance use and comorbidities research.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01HL146245-02S1
Application #
10131011
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Altekruse, Sean Fitzgerald
Project Start
2019-04-01
Project End
2026-03-31
Budget Start
2020-07-01
Budget End
2021-03-31
Support Year
2
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Hektoen Institute for Medical Research
Department
Type
DUNS #
068625136
City
Chicago
State
IL
Country
United States
Zip Code
60608