The goal of this proposal is to continue to assess the impact of new vaccines and vaccine policies on disease prevention through the Enhanced Surveillance for New Vaccine Preventable Diseases cooperative agreement.
Our specific aims i nclude: 1) conducting active population-based surveillance for vaccine preventable diseases throughout the Nashville/Davidson County population and performing epidemiologic and health services research on vaccine impact by utilizing the Tennessee Medicaid database;2) assessing issues related to provider implementation of new vaccine recommendations;and 3) enhancing inpatient and outpatient surveillance of children with fever and/or acute respiratory disease in Davidson County. A particular focus of our work during the upcoming funding period will be on influenza. With the new recommendation of routine influenza vaccination for children ages 6 -23 months, an immunization survey will be conducted in area practices to determine the influenza vaccine coverage rate for healthy children ages 6- 23 months, as well as older children with high-risk medical conditions in a representative sample of County children. In addition, surveys of primary care providers will help determine provider and practice characteristics that influence adoption of these new vaccine recommendations. Influenza vaccine effectiveness will evaluated for the 2003-2004 and 2004-2005 influenza seasons using a case cohort design. Exposure to influenza vaccine will use data obtained from the outpatient practice survey. Cases will be identified with augmented inpatient surveillance which will attempt to enroll all County children aged <5 years hospitalized with influenza 6 days/week as well as a representative sample of children seen only in the emergency room for influenza. These data will be instrumental in assessingthe impact of the new influenza vaccination recommendations. The utility of this network in evaluating new vaccines and vaccine policies is great.

Agency
National Institute of Health (NIH)
Institute
National Center for Immunication and Respiratory Diseases (NCIRD)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01IP000022-05S2
Application #
8131289
Study Section
Special Emphasis Panel (ZIP1-CTG (01))
Program Officer
Hopkins, Andrew S
Project Start
2004-09-30
Project End
2011-09-29
Budget Start
2010-09-30
Budget End
2011-09-29
Support Year
5
Fiscal Year
2010
Total Cost
$497,561
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pediatrics
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Hilmes, Melissa A; Daniel Dunnavant, F; Singh, Sudha P et al. (2017) Chest radiographic features of human metapneumovirus infection in pediatric patients. Pediatr Radiol 47:1745-1750
Nicholson, Maribeth R; Van Horn, Gerald T; Tang, Yi-Wei et al. (2016) Using Multiplex Molecular Testing to Determine the Etiology of Acute Gastroenteritis in Children. J Pediatr 176:50-56.e2
Abedi, Glen R; Prill, Mila M; Langley, Gayle E et al. (2016) Estimates of Parainfluenza Virus-Associated Hospitalizations and Cost Among Children Aged Less Than 5 Years in the United States, 1998-2010. J Pediatric Infect Dis Soc 5:7-13
Jules, Astride; Grijalva, Carlos G; Zhu, Yuwei et al. (2015) Influenza-related hospitalization and ED visits in children less than 5 years: 2000-2011. Pediatrics 135:e66-74
Oliveira, Danielle B L; Iwane, Marika K; Prill, Mila M et al. (2015) Molecular characterization of respiratory syncytial viruses infecting children reported to have received palivizumab immunoprophylaxis. J Clin Virol 65:26-31
Esbenshade, Jennifer C; Edwards, Kathryn M; Esbenshade, Adam J et al. (2013) Respiratory virus shedding in a cohort of on-duty healthcare workers undergoing prospective surveillance. Infect Control Hosp Epidemiol 34:373-8
Edwards, Kathryn M; Zhu, Yuwei; Griffin, Marie R et al. (2013) Burden of human metapneumovirus infection in young children. N Engl J Med 368:633-43
Iwane, Marika K; Chaves, Sandra S; Szilagyi, Peter G et al. (2013) Disparities between black and white children in hospitalizations associated with acute respiratory illness and laboratory-confirmed influenza and respiratory syncytial virus in 3 US counties--2002-2009. Am J Epidemiol 177:656-65
Poehling, Katherine A; Edwards, Kathryn M; Griffin, Marie R et al. (2013) The burden of influenza in young children, 2004-2009. Pediatrics 131:207-16
Hall, Caroline Breese; Weinberg, Geoffrey A; Blumkin, Aaron K et al. (2013) Respiratory syncytial virus-associated hospitalizations among children less than 24 months of age. Pediatrics 132:e341-8

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