To define the nature and extent of influenza (and other respiratory pathogens) associated Severe Acute Respiratory Infection (SARI) amongst urban and rural high-risk adults and children in Malawi in an area with highly endemic malaria and a high HIV prevalence. In the context of circulating influenza viruses, this work will focus SARI amongst those children under 1 year old, pregnant mothers and HIV infected adults admitted with and without malaria to a large Central Hospital in urban Malawi (Blantyre) and a rural site (Chikhwawa). The proximity of a MLW research facility based in Cikhwawa with a high malaria burden to the main MLW laboratory in Blantyre, provides a unique opportunity to make comparisons between rural and urban, and high and low malaria endemic populations.

Public Health Relevance

To define the nature and extent of influenza (and other respiratory pathogens) associated Severe Acute Respiratory Infection (SARI) amongst urban and rural high-risk adults and children in Malawi in an area with highly endemic malaria and a high HIV prevalence. In the context of circulating influenza viruses, this work will focus SARI amongst those children under 1 year old, pregnant mothers and HIV infected adults admitted with and without malaria to a large Central Hospital in urban Malawi (Blantyre) and a rural site (Chikhwawa). The proximity of a MLW research facility based in Cikhwawa with a high malaria burden to the main MLW laboratory in Blantyre, provides a unique opportunity to make comparisons between rural and urban, and high and low malaria endemic populations.

Agency
National Institute of Health (NIH)
Institute
National Center for Immunication and Respiratory Diseases (NCIRD)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01IP000848-02
Application #
8901784
Study Section
Special Emphasis Panel (ZIP1-GCA (26))
Program Officer
Loveys, Deborah
Project Start
2014-08-01
Project End
2019-07-31
Budget Start
2015-08-01
Budget End
2016-07-31
Support Year
2
Fiscal Year
2015
Total Cost
$1,200,000
Indirect Cost
Name
University of Liverpool
Department
Type
DUNS #
210308323
City
Liverpool
State
Country
United Kingdom
Zip Code
L69 3-BX