The proposed studies will provide critical information to inform immunization policies and practices in the United States. Immunizations are among the most effective health interventions available in the US, with more than 40,000 early deaths and 20 million cases of disease averted within each vaccinated birth cohort. Immunizations are also among the most efficient from an economic perspective. Many older vaccines are cost- saving, while newer vaccines require an investment for health benefits but typically yield cost-effectiveness ratios within a range considered to be cost-effective. As newer vaccines are associated with higher prices and also more likely to avert morbidity than mortality, economic evaluation can provide insights into the value of a new vaccine by weighing trade-offs among the additional investments required, averted disease costs, projected health benefits, and adverse events. The goal of these studies, as part of the Joint Initiative in Vaccine Economics (JIVE), is to address two highly-relevant topics in immunization policy and practice: the economic attractiveness of a hypothetical vaccine for respiratory syncytial virus (RSV) and the costs and potential health benefits of interoperability between provider practices and statewide immunization information systems. Using economic evaluation and decision analysis methods, we will (1) measure the economic burden associated with RSV for patients, caregivers, and family members at both the patient and population level; (2) evaluate projected health and economic outcomes for a hypothetical RSV vaccine, including costs, quality- adjusted life years, and incremental cost-effectiveness ratios, and (3) evaluate practice-level costs and benefits of interoperability between provider practice electronic health records and a statewide immunization information system. Methods will include primary data collection, health utility elicitation, discrete choice experiments, economic evaluation, simulation modeling, dynamic transmission modeling, as well as qualitative analysis.

Public Health Relevance

The goal of this proposed research study is to address two high-priority topics in immunization policy and practice using economic evaluation and decision analysis methodologies. The first study will measure the potential benefits of a hypothetical vaccine for respiratory syncytial virus. The second study will quantify the value of interoperability between provider practice electronic health records and a statewide immunization information system.

Agency
National Institute of Health (NIH)
Institute
National Center for Immunication and Respiratory Diseases (NCIRD)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01IP001104-01
Application #
9654270
Study Section
Special Emphasis Panel (ZIP1)
Project Start
2018-09-01
Project End
2021-08-31
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Pediatrics
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109