Early childhood temperament, particularly behavioral inhibition, is seen as an expression of a child's biologically based negative reactivity to novelty and threat. Behavioral inhibited children have difficulty with peer interactions and exhibit withdrawal in novel social situations. Although expressed behavior may change with development, the underlying tendencies and general thresholds for attending to and reacting to novel or threatening stimuli in the environment may remain stable. These differences in reactivity may influence patterns of social competence particularly as individuals enter into periods of change and transition in their social contexts. . The period of young adulthood may be of particular importance in the lives of behaviorally inhibited individuals since it is marked by structural and cultural changes in the individual's social environment. This period also marks the peak for the emergence of anxiety disorders and substance use. Insofar as behavioral inhibition selectively influences the direction of attention to threat (i.e., anxiety) and the likelihood of engaging in substance use these individuals may be most at-risk for the development of maladaptive outcomes in young adulthood. We propose to study the mechanisms involving attention bias to threat and anticipation of reward and their role in the formation of personality and the emergence of psychopathology and substance use within a sample of 20-year-olds who were initially selected for differences in temperamental reactivity including behavioral inhibition. These subjects have been followed in a longitudinal study since they were four months of age. At multiple age points, measures of temperament, social behavior, physiological reactivity, and cognitive processing were obtained. The subjects in the current study will be seen for a two-day visit where they will be assessed for psychiatric status, and then presented with two different tasks during functional neuroimaging. The two tasks include assessment of their attention bias to threat and assessment of their reactivity to reward anticipation. We will also collect questionnaire data, via internet methods, on each subject and a peer nominated by the target subject. The goal is to identify developmental trajectories from early childhood temperament to psychiatric outcomes and substance use and examine the mediating effects of social competence and the moderating roles of attention to threat and reward processing.

Public Health Relevance

The goal of this is to examine how the trajectories of childhood temperament predict the behavioral and neural correlates of attention bias to threat and incentive for reward in young adults with a history of behavioral inhibition, focusing specifically on the manner in which these processes moderate the association between temperament and anxiety disorders and substance use. Results from these studies will inform both prevention and intervention of anxiety disorders and associated substance use.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01MH074454-05
Application #
7937775
Study Section
Psychosocial Development, Risk and Prevention Study Section (PDRP)
Program Officer
Garriock, Holly A
Project Start
2009-09-23
Project End
2012-08-31
Budget Start
2010-09-01
Budget End
2012-08-31
Support Year
5
Fiscal Year
2010
Total Cost
$662,155
Indirect Cost
Name
University of Maryland College Park
Department
Other Health Professions
Type
Schools of Education
DUNS #
790934285
City
College Park
State
MD
Country
United States
Zip Code
20742
White, Lauren K; Degnan, Kathryn A; Henderson, Heather A et al. (2017) Developmental Relations Among Behavioral Inhibition, Anxiety, and Attention Biases to Threat and Positive Information. Child Dev 88:141-155
Pine, Daniel S; Fox, Nathan A (2015) Childhood antecedents and risk for adult mental disorders. Annu Rev Psychol 66:459-85
Degnan, Kathryn A; Almas, Alisa N; Henderson, Heather A et al. (2014) Longitudinal trajectories of social reticence with unfamiliar peers across early childhood. Dev Psychol 50:2311-2323
Pérez-Edgar, Koraly; Hardee, Jillian E; Guyer, Amanda E et al. (2014) DRD4 and striatal modulation of the link between childhood behavioral inhibition and adolescent anxiety. Soc Cogn Affect Neurosci 9:445-53
Fedota, John R; Hardee, Jillian E; Pérez-Edgar, Koraly et al. (2014) Representation of response alternatives in human presupplementary motor area: multi-voxel pattern analysis in a go/no-go task. Neuropsychologia 56:110-118
Gershon, Richard C; Wagster, Molly V; Hendrie, Hugh C et al. (2013) NIH toolbox for assessment of neurological and behavioral function. Neurology 80:S2-6
Weintraub, Sandra; Dikmen, Sureyya S; Heaton, Robert K et al. (2013) Cognition assessment using the NIH Toolbox. Neurology 80:S54-64
Hardee, Jillian E; Benson, Brenda E; Bar-Haim, Yair et al. (2013) Patterns of neural connectivity during an attention bias task moderate associations between early childhood temperament and internalizing symptoms in young adulthood. Biol Psychiatry 74:273-9
Victorson, David; Manly, Jennifer; Wallner-Allen, Kathleen et al. (2013) Using the NIH Toolbox in special populations: considerations for assessment of pediatric, geriatric, culturally diverse, non-English-speaking, and disabled individuals. Neurology 80:S13-9
Fox, Nathan A; Pine, Daniel S (2012) Temperament and the emergence of anxiety disorders. J Am Acad Child Adolesc Psychiatry 51:125-8

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