The Neurologic AIDS Research Consortium (NARC) will maintain an effective collaborative clinical study group dedicated to the study of HIV-associated neurologic disease. Projects are identified by investigators, designed with review by internal and external experts and implemented. This proposal includes completion of currently active studies, and initiation of new areas of investigation relevant to the neurologic complications associated with HIV infection. The specific projects to be undertaken include: 1. Complete and analyze A5090 testing the safety and efficacy of transdermal selegiline for HIV- associated motor cognitive disorder; 2. Monitor the incidence, prevalence and natural history of HIV related neuropathy and neuropsychologic disorders and validate brief screens for detection of central and peripheral nervous system dysfunction in the Adult Longitudinal Linked Retroviral Treatment (ALLRT) Cohort of the AIDS Clinical Trial Group; 3. Complete and analyze longitudinal physiologic and morphologic characterization of distal sensory neuropathy in HIV over a one year period of observation; 4. Complete and analyze our study of the virologic, immunologic and pharmacologic manifestations of HIV in CSF compartment during anti-retroviral treatment; 5. Perform a study of Acetyl L-carnitine for treatment of dideoxynucleoside induced painful neuropathy in HIV infection; 6. Develop and implement a study to measure the safety, tolerability and analgesic properties of Prosaptide for HIV-associated painful peripheral neuropathy; and 7. Characterize the newly described acute neuromuscular disorder associated with lactic acidosis seen in treated HIV patients. Major studies will be developed and operated cooperatively with the AIDS Clinical Trial Group (ACTG). The NARC will continue to develop a broad agenda for clinical study of neuroAIDS complications following these studies, directed by the Principal Investigator, Executive Steering committee and the NINDS appointed Data and Safety Monitoring Board (DSMB).

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZNS1-SRB-A (02))
Program Officer
Nunn, Michael
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Schools of Medicine
Saint Louis
United States
Zip Code
Obermeit, Lisa C; Beltran, Jessica; Casaletto, Kaitlin B et al. (2017) Evaluating the accuracy of self-report for the diagnosis of HIV-associated neurocognitive disorder (HAND): defining ""symptomatic"" versus ""asymptomatic"" HAND. J Neurovirol 23:67-78
Malvar, Jemily; Vaida, Florin; Sanders, Chelsea Fitzsimons et al. (2015) Predictors of new-onset distal neuropathic pain in HIV-infected individuals in the era of combination antiretroviral therapy. Pain 156:731-9
Lee, Anthony J; Bosch, Ronald J; Evans, Scott R et al. (2015) Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen. J Neurovirol 21:210-8
Grant, Igor; Franklin Jr, Donald R; Deutsch, Reena et al. (2014) Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline. Neurology 82:2055-62
Sacktor, Ned; Miyahara, Sachiko; Evans, Scott et al. (2014) Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. J Neurovirol 20:620-6
Zhang, Xinyan; Tierney, Camlin; Albrecht, Mary et al. (2013) Discordant associations between SLCO1B1 521T?C and plasma levels of ritonavir-boosted protease inhibitors in AIDS clinical trials group study A5146. Ther Drug Monit 35:209-16
Chen, Huichao; Clifford, David B; Deng, Lijuan et al. (2013) Peripheral neuropathy in ART-experienced patients: prevalence and risk factors. J Neurovirol 19:557-64
Nakasujja, Noeline; Miyahara, Sachiko; Evans, Scott et al. (2013) Randomized trial of minocycline in the treatment of HIV-associated cognitive impairment. Neurology 80:196-202
Harrison, Taylor; Miyahara, Sachiko; Lee, Anthony et al. (2013) Experience and challenges presented by a multicenter crossover study of combination analgesic therapy for the treatment of painful HIV-associated polyneuropathies. Pain Med 14:1039-47
Nguyen, Anh; Rossi, Steven; Croteau, David et al. (2013) Etravirine in CSF is highly protein bound. J Antimicrob Chemother 68:1161-8

Showing the most recent 10 out of 68 publications