Mild cognitive impairment (MCI), dementia and stroke are substantially higher among blacks aged 45+, and among residents of the southeastern region of the US. The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study is national, longitudinal cohort study of ~ 30,000 blacks and whites designed to advance the understanding of the epidemiology of cognitive decline and stroke, and the contributors to racial and geographic disparities in these outcomes. The current application has three aims: 1. Identify social, cardiovascular, and environmental mechanisms of racial and geographic disparities in incident vascular contributions to cognitive impairment and dementia (VCID). With assessment in mid-life and over a decade of longitudinal cognitive data, REGARDS is uniquely positioned to identify vascular, social, and behavioral mechanisms underlying disparities in VCID, and modifiable pathways on which interventions may narrow disparities in VCID. After completion of a nested calibration/confirmation study to develop an algorithm for the classification of MCI and dementia, we will characterize racial and geographic disparities in VCID and determine if interventions on mediators would diminish or eliminate disparities. 2. Answer as-yet-unanswered questions in stroke and cerebrovascular disease epidemiology. By continuing the successful approaches for stroke surveillance among 17000 active cohort members, the study will assess the association of risk factor changes and novel biomarkers quantified with the completion of the second in-person exam with stroke risk and disparities in stroke risk. In addition, with the aging of the cohort, this aim will provide greatly needed information on stroke epidemiology in the elderly. 3. Utilize incident risk factor data and biospecimens to identify pathways for development of incident hypertension and diabetes, with the goal of understanding the impact on incident VCID and stroke. We have documented that ?30% of the racial disparity in stroke risk is attributable to racial disparities in prevalence of hypertension and diabetes, and the study will investigate the biomarker pathways contributing to the higher incidence of hypertension and diabetes in blacks. Each proposed aim addresses a topic of profound public health impact, and REGARDS progress to date uniquely positions the study to address these aims using proven approaches in an efficient manner.

Public Health Relevance

Mild cognitive impairment (MCI), dementia and stroke are substantially higher among blacks aged 45 and older, and among persons who live in the southeastern region of the US. The reasons for these higher rates are poorly understood. Analyses of vascular contributions to cognitive impairment and stroke from a national US cohort including persons with and without MCI, dementia, and stroke will help guide interventions to reduce these disparities.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Neurological, Aging and Musculoskeletal Epidemiology (NAME)
Program Officer
Corriveau, Roderick A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alabama Birmingham
Biostatistics & Other Math Sci
Schools of Public Health
United States
Zip Code
Colantonio, Lisandro D; Levitan, Emily B; Yun, Huifeng et al. (2018) Use of Medicare Claims Data for the Identification of Myocardial Infarction: The Reasons for Geographic And Racial Differences in Stroke Study. Med Care 56:1051-1059
Moore, Justin Xavier; Akinyemiju, Tomi; Bartolucci, Alfred et al. (2018) A prospective study of cancer survivors and risk of sepsis within the REGARDS cohort. Cancer Epidemiol 55:30-38
Sarmiento, Elisa J; Moore, Justin Xavier; McClure, Leslie A et al. (2018) Fine Particulate Matter Pollution and Risk of Community-Acquired Sepsis. Int J Environ Res Public Health 15:
Mefford, Matthew T; Rosenson, Robert S; Cushman, Mary et al. (2018) PCSK9 Variants, Low-Density Lipoprotein Cholesterol, and Neurocognitive Impairment: Reasons for Geographic and Racial Differences in Stroke Study (REGARDS). Circulation 137:1260-1269
Sterling, Madeline R; Durant, Raegan W; Bryan, Joanna et al. (2018) N-terminal pro-B-type natriuretic peptide and microsize myocardial infarction risk in the reasons for geographic and racial differences in stroke study. BMC Cardiovasc Disord 18:66
Colantonio, Lisandro D; Booth 3rd, John N; Bress, Adam P et al. (2018) 2017 ACC/AHA Blood Pressure Treatment Guideline Recommendations and Cardiovascular Risk. J Am Coll Cardiol 72:1187-1197
Sterling, Madeline R; Jannat-Khah, Deanna; Bryan, Joanna et al. (2018) The Prevalence of Cognitive Impairment Among Adults with Incident Heart Failure: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study. J Card Fail :
Inker, Lesley A; Grams, Morgan E; Levey, Andrew S et al. (2018) Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium. Am J Kidney Dis :
Marks, Kristin J; Hartman, Terryl J; Judd, Suzanne E et al. (2018) Dietary Oxidative Balance Scores and Biomarkers of Inflammation among Individuals with and without Chronic Kidney Disease. Nephron Extra 8:11-23
Dubin, Ruth F; Judd, Suzanne; Scherzer, Rebecca et al. (2018) Urinary Tubular Injury Biomarkers Are Associated With ESRD and Death in the REGARDS Study. Kidney Int Rep 3:1183-1192

Showing the most recent 10 out of 392 publications