Phenylpropanoid Analogs to Treat Stroke

Lapchak, Paul A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Project--Cooperative Agreements (U01)
• Project #: 5U01NS060685-03
• Application #: 8269697
• Study Section: National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
• Budget Start: 2011-09-01
• Budget End: 2012-08-31
• Support Year: 3
• Fiscal Year: 2011
• Total Cost: $1,222,527

Institution

• Name: Cedars-Sinai Medical Center
• DUNS #: 075307785
• City: Los Angeles
• State: CA
• Country: United States
• Zip Code: 90048

Publications

Lapchak, Paul A; Boitano, Paul D (2016) A novel method to promote behavioral improvement and enhance mitochondrial function following an embolic stroke. Brain Res 1646:125-131

Lapchak, Paul A (2015) A cost-effective rabbit embolic stroke bioassay: insight into the development of acute ischemic stroke therapy. Transl Stroke Res 6:99-103

Lapchak, Paul A; Daley, Jessica T; Boitano, Paul D (2015) A blinded, randomized study of L-arginine in small clot embolized rabbits. Exp Neurol 266:143-6

Lapchak, Paul A (2015) Neuronal Dysregulation in Stroke-Associated Pseudobulbar Affect (PBA): Diagnostic Scales and Current Treatment Options. J Neurol Neurophysiol 6:

Lapchak, Paul A (2015) Critical early thrombolytic and endovascular reperfusion therapy for acute ischemic stroke victims: a call for adjunct neuroprotection. Transl Stroke Res 6:345-54

Lapchak, Paul A; Lara, Jacqueline A; Boitano, Paul D (2014) 4-((1E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-phenyl-1H-pyrazoyl-3-yl) vinyl)-2-methoxy-phenol) (CNB-001) Does Not Regulate Human Recombinant Protein-Tyrosine Phosphatase1B (PTP1B) Activity in vitro. J Neurol Neurophysiol 5:

Panzhinskiy, Evgeniy; Hua, Yinan; Lapchak, Paul A et al. (2014) Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance. J Pharmacol Exp Ther 349:248-57

Lapchak, Paul A; Boitano, Paul D (2014) Effect of the Pleiotropic Drug CNB-001 on Tissue Plasminogen Activator (tPA) Protease Activity in vitro: Support for Combination Therapy to Treat Acute Ischemic Stroke. J Neurol Neurophysiol 5:

Lapchak, Paul A (2013) Drug-like property profiling of novel neuroprotective compounds to treat acute ischemic stroke: guidelines to develop pleiotropic molecules. Transl Stroke Res 4:328-42

Lapchak, Paul A; Zhang, John H; Noble-Haeusslein, Linda J (2013) RIGOR guidelines: escalating STAIR and STEPS for effective translational research. Transl Stroke Res 4:279-85