Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01NS060685-03
Application #
8269697
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
3
Fiscal Year
2011
Total Cost
$1,222,527
Indirect Cost
Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048
Lapchak, Paul A; Boitano, Paul D (2016) A novel method to promote behavioral improvement and enhance mitochondrial function following an embolic stroke. Brain Res 1646:125-131
Lapchak, Paul A (2015) A cost-effective rabbit embolic stroke bioassay: insight into the development of acute ischemic stroke therapy. Transl Stroke Res 6:99-103
Lapchak, Paul A; Daley, Jessica T; Boitano, Paul D (2015) A blinded, randomized study of L-arginine in small clot embolized rabbits. Exp Neurol 266:143-6
Lapchak, Paul A (2015) Neuronal Dysregulation in Stroke-Associated Pseudobulbar Affect (PBA): Diagnostic Scales and Current Treatment Options. J Neurol Neurophysiol 6:
Lapchak, Paul A (2015) Critical early thrombolytic and endovascular reperfusion therapy for acute ischemic stroke victims: a call for adjunct neuroprotection. Transl Stroke Res 6:345-54
Lapchak, Paul A; Lara, Jacqueline A; Boitano, Paul D (2014) 4-((1E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-phenyl-1H-pyrazoyl-3-yl) vinyl)-2-methoxy-phenol) (CNB-001) Does Not Regulate Human Recombinant Protein-Tyrosine Phosphatase1B (PTP1B) Activity in vitro. J Neurol Neurophysiol 5:
Panzhinskiy, Evgeniy; Hua, Yinan; Lapchak, Paul A et al. (2014) Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance. J Pharmacol Exp Ther 349:248-57
Lapchak, Paul A; Boitano, Paul D (2014) Effect of the Pleiotropic Drug CNB-001 on Tissue Plasminogen Activator (tPA) Protease Activity in vitro: Support for Combination Therapy to Treat Acute Ischemic Stroke. J Neurol Neurophysiol 5:
Lapchak, Paul A (2013) Fast neuroprotection (fast-NPRX) for acute ischemic stroke victims: the time for treatment is now. Transl Stroke Res 4:704-9
Lapchak, Paul A (2013) Drug-like property profiling of novel neuroprotective compounds to treat acute ischemic stroke: guidelines to develop pleiotropic molecules. Transl Stroke Res 4:328-42

Showing the most recent 10 out of 35 publications