Abstract

This project proposes the mining of plasma and cerebrospinal fluid (CSF) biomarkers of disease progression in Huntington Disease (HD) using the latest analytical tools to accelerate future treatment studies.

Public Health Relevance

Tracking the onset and progression of HD using molecular biomarkers would be a desired, practical and inexpensive tool that can strongly compliment clinical and physiological measures and that would provide valuable information for clinical decision-making and drug development for the HD community. Since there are both peripheral and central nervous system (CNS) manifestations of the disease that can provide for biomarkers, we propose to include cerebral spinal fluid (CSF), in addition to the current plasma collection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01NS082089-02
Application #
8740576
Study Section
Special Emphasis Panel (ZNS1-SRB-G (64))
Program Officer
Sutherland, Margaret L
Project Start
2013-09-25
Project End
2016-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
2
Fiscal Year
2014
Total Cost
$548,273
Indirect Cost
$45,927

  Institution

Name
University of Iowa
Department
Psychiatry
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Paulsen, Jane S; Long, Jeffrey D (2014) Onset of Huntington's disease: can it be purely cognitive? Mov Disord 29:1342-50