The Division of Pediatric Hematology/Oncology, Columbia- Presbyterian Medical Center (Columbia) will continue its participation in the Children's Cancer Study Group of which it has been a member since 1957. The purpose of these studies is to devise optimal management for childhood cancer, and to evaluate the biology of childhood tumors. The group at Columbia together with its major affiliate, the Division of Pediatric Hematology/Oncology at New York University, will enter in studies designed in cooperation with other members of the Children's Cancer Study Group all patients with childhood cancer; it will provide management standardized to group requirements, including all required laboratory investigations and biological sampling, for all patients; it will keep accurate records and transmit them promptly to the Group Headquarters for evaluation. In addition to patient entry, investigators from the group at Columbia will participate in protocol design and strategy of experimental approach, providing the input of their expertise and specific resources. Significant contributions will be made to CCSG studies, particularly in the area of brain tumors and new agent studies. The large number of children with brain tumors operated on both at Columbia and at New York University (two of the most active Pediatric Neurosurgery Centers in the Country) will be an invaluable resource to CCSG. Both institutions have now very active Pediatric Neuro-Oncology services. Research in the area of childhood cancer will be fostered, with an eye to providing research input that could lead to group-wide experimentation. The areas under current investigations include: studies of the N-myc oncogene in childhood tumor; studies of cellular differentiation; studies of brain tumors biology; studies of immunophenotypes of leukemia and studies of the endocrine effects of cancer treatment.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Cancer Clinical Investigation Review Committee (CCI)
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Columbia University (N.Y.)
Schools of Medicine
New York
United States
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Shamberger, Robert C; LaQuaglia, Michael P; Gebhardt, Mark C et al. (2003) Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg 238:563-7; discussion 567-8
Davies, Stella M; Bhatia, Smita; Ross, Julie A et al. (2002) Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia. Blood 100:67-71
Lange, Beverly J; Bostrom, Bruce C; Cherlow, Joel M et al. (2002) Double-delayed intensification improves event-free survival for children with intermediate-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group. Blood 99:825-33
Ou, Shu Xiao; Han, Dehui; Severson, Richard K et al. (2002) Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States). Cancer Causes Control 13:15-25
Cairo, M S; Krailo, M D; Morse, M et al. (2002) Long-term follow-up of short intensive multiagent chemotherapy without high-dose methotrexate ('Orange') in children with advanced non-lymphoblastic non-Hodgkin's lymphoma: a children's cancer group report. Leukemia 16:594-600
Wells, R J; Arthur, D C; Srivastava, A et al. (2002) Prognostic variables in newly diagnosed children and adolescents with acute myeloid leukemia: Children's Cancer Group Study 213. Leukemia 16:601-7
Cooper, R; Khakoo, Y; Matthay, K K et al. (2001) Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: histopathologic features-a report from the Children's Cancer Group. Med Pediatr Oncol 36:623-9
Sposto, R; Meadows, A T; Chilcote, R R et al. (2001) Comparison of long-term outcome of children and adolescents with disseminated non-lymphoblastic non-Hodgkin lymphoma treated with COMP or daunomycin-COMP: A report from the Children's Cancer Group. Med Pediatr Oncol 37:432-41
Woods, W G; Nesbit, M E; Buckley, J et al. (1985) Correlation of chromosome abnormalities with patient characteristics, histologic subtype, and induction success in children with acute nonlymphocytic leukemia. J Clin Oncol 3:3-11