This research proposal relates to participation of The Albany Medical College and its affiliated institutions in the clinical intervention and related studies of the Eastern Cooperative Oncology Group (ECOG) that are designed to demonstrate methods that will reduce morbidity and mortality from cancer. The College's organizationally stable and multimodality program will provide scientific and administrative leadership, and active participation in the development, performance, evaluation, and reporting of well performed cooperative clinical studies of patients with a wide variety of common and rare solid tumors as well as patients with lymphomas, Hodgkin's Disease, myeloma and acute and chronic leukemia. Emphasis is placed on adjuvant studies, and the modalities and technics of surgery, pathology, radiation therapy, chemotherapy, immunotherapy and biologic response modifiers will all be utilized. Epidemiologic studies will be included and, in addition, patients at high risk for developing cancer will be enrolled in the important new cancer prevention studies of the group. In addition to the group-wide studies, the College will perform pilot studies that will lead to subsequent group-wide trials. Continued accuracy and timeliness of data submission and evaluation will be maintained by an ongoing audit process, and facilitated by a phased development of electronic mail and computerization of clinical data handling. Thus, the program is both providing as well as responding to new scientific and technical initiatives. As evidenced by the incorporation of a CCOP into its program, it is also responding to changing administrative needs. It is thereby in a strong position to meet its important and expanding clinical research goals aimed at reducing the overall impact of cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA006594-28
Application #
3555867
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1978-06-01
Project End
1994-04-30
Budget Start
1992-05-01
Budget End
1993-04-30
Support Year
28
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Albany Medical College
Department
Type
Schools of Medicine
DUNS #
City
Albany
State
NY
Country
United States
Zip Code
12208
Sparano, Joseph A; Weller, Edie; Nazeer, Tipu et al. (2002) Phase 2 trial of infusional cyclophosphamide, doxorubicin, and etoposide in patients with poor-prognosis, intermediate-grade non-Hodgkin lymphoma: an Eastern Cooperative Oncology Group trial (E3493). Blood 100:1634-40
Kucuk, O; Young, M L; Habermann, T M et al. (2000) Phase II trail of didemnin B in previously treated non-Hodgkin's lymphoma: an Eastern Cooperative Oncology Group (ECOG) Study. Am J Clin Oncol 23:273-7
Leaf, A N; Wolf, B C; Kirkwood, J M et al. (2000) Phase II study of etoposide (VP-16) in patients with thyroid cancer with no prior chemotherapy: an Eastern Cooperative Oncology Group Study (E1385). Med Oncol 17:47-51
Einzig, A I; Neuberg, D; Remick, S C et al. (1996) Phase II trial of docetaxel (Taxotere) in patients with adenocarcinoma of the upper gastrointestinal tract previously untreated with cytotoxic chemotherapy: the Eastern Cooperative Oncology Group (ECOG) results of protocol E1293. Med Oncol 13:87-93
Falkson, G; Lipsitz, S; Borden, E et al. (1995) Hepatocellular carcinoma. An ECOG randomized phase II study of beta-interferon and menogaril. Am J Clin Oncol 18:287-92
Chang, A Y; Kim, K; Glick, J et al. (1993) Phase II study of taxol, merbarone, and piroxantrone in stage IV non-small-cell lung cancer: The Eastern Cooperative Oncology Group Results. J Natl Cancer Inst 85:388-94
Cummings, F J; Gray, R; Tormey, D C et al. (1993) Adjuvant tamoxifen versus placebo in elderly women with node-positive breast cancer: long-term follow-up and causes of death. J Clin Oncol 11:29-35
Friedenberg, W R; Anderson, J; Wolf, B C et al. (1993) Modified vincristine, doxorubicin, and dexamethasone regimen in the treatment of resistant or relapsed chronic lymphocytic leukemia. An Eastern Cooperative Oncology Group study. Cancer 71:2983-9
Wolf, B C; Sheahan, K; DeCoste, D et al. (1992) Immunohistochemical analysis of small cell tumors of the thyroid gland: an Eastern Cooperative Oncology Group study. Hum Pathol 23:1252-61
Smalley, R V; Andersen, J W; Hawkins, M J et al. (1992) Interferon alfa combined with cytotoxic chemotherapy for patients with non-Hodgkin's lymphoma. N Engl J Med 327:1336-41

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