To participate in the planning and implementation of Cancer and Leukemia Group B (CALGB) studies in solid tumors, leukemia and lymphoma. These studies aim at the definition of optimum treatment programs for the management of patients with all types of cancer. Such programs include randomized controlled, multidisciplinary studies (Phase III) and single arm studies of new drugs or radiotherapy (Phase II). To undertake pilot treatment studies that can be brought to CALGB for expanded study. These will include traditional combination chemotherapy trials in advanced cancer, studies of chemotherapy prior to the use of surgery and/or radiation therapy in patients with known poor prognosis, and development of drug combinations through laboratory and clinical investigation into rational sequencing of antimetabolites. To assist in providing chemotherapeutic, surgical and radiotherapeutic expertise for treatment of patients with neoplastic disease. Patients are situated at four affiliated hospitals in New York City (Presbyterian, St. Luke's, Roosevelt and Harlem), in the Northern New Jersey Community Clinical Oncology Program (CCOP) and at Valley Hospital in Ridgewood, New Jersey. To initiate and participate in cancer education programs for medical students, medical, surgical and radiotherapy housestaff, and hematology/oncology fellows at all of the New York City hospitals named.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA012011-13
Application #
3556010
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1978-07-01
Project End
1988-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
13
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
Schools of Medicine
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027
Paschka, Peter; Marcucci, Guido; Ruppert, Amy S et al. (2006) Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study. J Clin Oncol 24:3904-11
Muss, Hyman B; Woolf, Susan; Berry, Donald et al. (2005) Adjuvant chemotherapy in older and younger women with lymph node-positive breast cancer. JAMA 293:1073-81
Coleman, M; Rafla, S; Propert, K J et al. (1998) Augmented therapy of extensive Hodgkin's disease: radiation to known disease or prolongation of induction chemotherapy did not improve survival--results of a Cancer and Leukemia Group B study. Int J Radiat Oncol Biol Phys 41:639-45
Tross, S; Herndon 2nd, J; Korzun, A et al. (1996) Psychological symptoms and disease-free and overall survival in women with stage II breast cancer. Cancer and Leukemia Group B. J Natl Cancer Inst 88:661-7
Aisner, J; Cirrincione, C; Perloff, M et al. (1995) Combination chemotherapy for metastatic or recurrent carcinoma of the breast--a randomized phase III trial comparing CAF versus VATH versus VATH alternating with CMFVP: Cancer and Leukemia Group B Study 8281. J Clin Oncol 13:1443-52
Davey, F R; Abraham Jr, N; Brunetto, V L et al. (1995) Morphologic characteristics of erythroleukemia (acute myeloid leukemia;FAB-M6): a CALGB study. Am J Hematol 49:29-38
Ozer, H; Anderson, J R; Peterson, B A et al. (1994) Combination trial of subcutaneous recombinant alpha 2 b interferon and oral cyclophosphamide in follicular low-grade non-Hodgkin's lymphoma. Med Pediatr Oncol 22:228-35
Luikart, S D; Goutsou, M; Mitchell, E D et al. (1993) Phase I/II trial of etoposide and carboplatin in extensive small-cell lung cancer. A report from the Cancer and Leukemia Group B. Am J Clin Oncol 16:127-31
Ellison, R R; Mick, R; Cuttner, J et al. (1991) The effects of postinduction intensification treatment with cytarabine and daunorubicin in adult acute lymphocytic leukemia: a prospective randomized clinical trial by Cancer and Leukemia Group B. J Clin Oncol 9:2002-15
Graziano, S L; Lee, K; Propert, K J et al. (1990) Phase II trial of etoposide and cisplatin for refractory small cell lung cancer: a Cancer and Leukemia Group B Study. Med Pediatr Oncol 18:22-6

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