The Division of Radiation Oncology at Washington University proposes to: 1) Continue participation in clinical trials of the Radiation Therapy Oncology Group; 2) contribute to the scientific contents of group studies and to actively engage in protocol design and coordination; 3) assist in administrative and organizational matters of the group outlined by the Chairman of the Group and Committee Chairmen; 4) participate in the analysis of scientific data generated by the Radiation Therapy Oncology Group and to prepare manuscripts to be submitted for publication to reputable scientific journals; 5) promote clinical trials within the framework of cooperative groups at Washington University School of Medicine. The Division has consistently been one of the major contributors of patients to RTOG protocol studies. Approximately 50% of the patients accessioned to the studies have been in non-metastatic protocols. The projected number of patients to be entered in protocol studies during the year 1979 will be in the range of 90 to 100. The Division participates in the avant-garde protocols in radiation oncology that require specialized facilities and equipment such as the hyperthermia and hypoxic sensitizers.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
3U10CA012261-17S1
Application #
3556117
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1979-02-01
Project End
1989-06-30
Budget Start
1989-04-01
Budget End
1989-06-30
Support Year
17
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Martin, L A; Krall, J M; Curran, W J et al. (1995) Influence of a sampling review process for radiation oncology quality assurance in cooperative group clinical trials--results of the Radiation Therapy Oncology Group (RTOG) analysis. Radiother Oncol 36:9-14
Perez, C A; Pajak, T; Emami, B et al. (1991) Randomized phase III study comparing irradiation and hyperthermia with irradiation alone in superficial measurable tumors. Final report by the Radiation Therapy Oncology Group. Am J Clin Oncol 14:133-41
Emami, B; Myerson, R J; Scott, C et al. (1991) Phase I/II study, combination of radiotherapy and hyperthermia in patients with deep-seated malignant tumors: report of a pilot study by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 20:73-9
Coleman, C N; Wasserman, T H; Urtasun, R C et al. (1990) Final report of the phase I trial of the hypoxic cell radiosensitizer SR 2508 (etanidazole) Radiation Therapy Oncology Group 83-03. Int J Radiat Oncol Biol Phys 18:389-93
Perez, C A; Gillespie, B; Pajak, T et al. (1989) Quality assurance problems in clinical hyperthermia and their impact on therapeutic outcome: a Report by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 16:551-8
Perez, C A; Bauer, M; Emami, B N et al. (1988) Thoracic irradiation with or without levamisole (NSC #177023) in unresectable non-small cell carcinoma of the lung: a phase III randomized trial of the RTOG. Int J Radiat Oncol Biol Phys 15:1337-46
Simpson, J R; Bauer, M; Wasserman, T H et al. (1987) Large fraction irradiation with or without misonidazole in advanced non-oat cell carcinoma of the lung: a phase III randomized trial of the RTOG. Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 13:861-7
Coleman, C N; Wasserman, T H; Urtasun, R C et al. (1986) Phase I trial of the hypoxic cell radiosensitizer SR-2508: the results of the five to six week drug schedule. Int J Radiat Oncol Biol Phys 12:1105-8