Personnel listed in this grant application constitute a group of clinical investigators in the field of Surgical, Radiation or Medical Oncology who collectively are recognized and accepted as a member institution of the Cancer and Leukemia Group B (CALGB). Mass. General Hospital investigators in Boston, Ma. share the goals of the CALGB to collaborate in the prosecution of clinical investigations in adult neoplasms including acute and chronic leukemias, lymphomas, respiratory cancer, breast cancer and a limited number of other solid tumors.
The aim of the group is to accrue as many patients as possible to the approved CALGB protocols and to prosecute these clinical studies with distinction. The protocols written by members of the CALGB incorporate experimental design appropriate to the phase of a particular investigation. In general, the group engages in Phase II protocols attempting to evaluate the role of new agents in selected diseases or Phase III protocols attempting to evaluate the relative effectiveness of 2 or more treatment strategies. By carrying on such studies, the group hopes to clarify optimal programs as treatment as rapidly as possible and to improve clinical management of patients with neoplastic diseases. The range of group studies may involve multidisciplinary studies incorporating pathologic review, chemotherapy, radiation therapy, immunotherapy and psychiatry or they may be limited to any one of these modalities. Principal investigator, Dr. Robert Carey, will have the responsibility of coordinating research activities of the affiliated Mass. General Hospital Investigators. The MGH Group is a consortium of experienced oncologists, surgeons, pathologists, psychiatrists, and internists concerned with aspects of neoplastic disease and who desire to work together in a non-coersive, voluntary association in order to answer important therapeutic questions in cancer management by participation in clinical studies of CALGB.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA012449-15
Application #
3556135
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1979-04-01
Project End
1988-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
15
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
Ogino, Shuji; Liao, Xiaoyun; Imamura, Yu et al. (2013) Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial. J Natl Cancer Inst 105:1789-98
Lichtman, S M; Hurria, A; Cirrincione, C T et al. (2012) Paclitaxel efficacy and toxicity in older women with metastatic breast cancer: combined analysis of CALGB 9342 and 9840. Ann Oncol 23:632-8
Garber, Judy E; Halabi, Susan; Tolaney, Sara M et al. (2010) Factor V Leiden mutation and thromboembolism risk in women receiving adjuvant tamoxifen for breast cancer. J Natl Cancer Inst 102:942-9
Smith, S M; Johnson, J; Cheson, B D et al. (2009) Recombinant interferon-alpha2b added to oral cyclophosphamide either as induction or maintenance in treatment-naive follicular lymphoma: final analysis of CALGB 8691. Leuk Lymphoma 50:1606-17
Grinblatt, David L; Yu, Daohai; Hars, Vera et al. (2009) Treatment of myelodysplastic syndrome with 2 schedules and doses of oral topotecan: a randomized phase 2 trial by the Cancer and Leukemia Group B (CALGB 19803). Cancer 115:84-93
Stinchcombe, Thomas E; Hodgson, Lydia; Herndon 2nd, James E et al. (2009) Treatment outcomes of different prognostic groups of patients on cancer and leukemia group B trial 39801: induction chemotherapy followed by chemoradiotherapy compared with chemoradiotherapy alone for unresectable stage III non-small cell lung cancer. J Thorac Oncol 4:1117-25
Katz, Mira L; Donohue, Kathleen A; Alfano, Catherine M et al. (2009) Cancer surveillance behaviors and psychosocial factors among long-term survivors of breast cancer. Cancer and Leukemia Group B 79804. Cancer 115:480-8
Alfano, Catherine M; Day, Jeannette M; Katz, Mira L et al. (2009) Exercise and dietary change after diagnosis and cancer-related symptoms in long-term survivors of breast cancer: CALGB 79804. Psychooncology 18:128-33
Blanke, Charles D; Rankin, Cathryn; Demetri, George D et al. (2008) Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033. J Clin Oncol 26:626-32
Bogart, Jeffrey A; Watson, Dorothy; McClay, Edward F et al. (2008) Interruptions of once-daily thoracic radiotherapy do not correlate with outcomes in limited stage small cell lung cancer: analysis of CALGB phase III trial 9235. Lung Cancer 62:92-8

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