The University of Wisconsin has been a leader in cooperative group trials for many years. This application requests the support necessary for continued participation in the Eastern Cooperative Oncology Group (ECOG) by the University of Wisconsin and its affiliated institutions.
The specific aims of this proposal include: (1) Participation in Phase I, II and III clinical trials of cancer treatment with particular emphasis on surgical adjuvant trials and on studies involving a combined modality approach to patients with advanced disease and participation in cancer control studies; (2) Development of innovative treatment and cancer control protocols; (3) Continued leadership in the scientific programs and administrative activities of ECOG; (4) Maintenance and refinement of an effective data management program; and (5) Promotion of accrual to ECOG studies through further development of the Outreach program for participating community hospitals. In order to accomplish these objectives, we have: (1) Assembled an outstanding team of investigators from a variety of clinical disciplines within the University of Wisconsin Center for Health sciences; (2) Established a centralized coordinating facility for data management; and (3) Developed a model program for the incorporation of community hospitals into the ECOG program through our ECOG Outreach activities.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA021076-16
Application #
3556566
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1978-06-01
Project End
1994-04-30
Budget Start
1991-05-01
Budget End
1992-04-30
Support Year
16
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Lubner, Sam; Feng, Yang; Mulcahy, Mary et al. (2018) E4206: AMG 706 and Octreotide in Patients with Low-Grade Neuroendocrine Tumors. Oncologist 23:1006-e104
Moots, Paul L; O'Neill, Anne; Londer, Harold et al. (2018) Preradiation Chemotherapy for Adult High-risk Medulloblastoma: A Trial of the ECOG-ACRIN Cancer Research Group (E4397). Am J Clin Oncol 41:588-594
Gravis, Gwenaelle; Boher, Jean-Marie; Chen, Yu-Hui et al. (2018) Burden of Metastatic Castrate Naive Prostate Cancer Patients, to Identify Men More Likely to Benefit from Early Docetaxel: Further Analyses of CHAARTED and GETUG-AFU15 Studies. Eur Urol 73:847-855
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Perez Horta, Zulmarie; Goldberg, Jacob L; Sondel, Paul M (2016) Anti-GD2 mAbs and next-generation mAb-based agents for cancer therapy. Immunotherapy 8:1097-117
Haas, Naomi B; Manola, Judith; Uzzo, Robert G et al. (2016) Adjuvant sunitinib or sorafenib for high-risk, non-metastatic renal-cell carcinoma (ECOG-ACRIN E2805): a double-blind, placebo-controlled, randomised, phase 3 trial. Lancet 387:2008-16
Wang, Wei; Erbe, Amy K; Gallenberger, Mikayla et al. (2016) Killer immunoglobulin-like receptor (KIR) and KIR-ligand genotype do not correlate with clinical outcome of renal cell carcinoma patients receiving high-dose IL2. Cancer Immunol Immunother 65:1523-1532
Barta, Stefan K; Li, Hailun; Hochster, Howard S et al. (2016) Randomized phase 3 study in low-grade lymphoma comparing maintenance anti-CD20 antibody with observation after induction therapy: A trial of the ECOG-ACRIN Cancer Research Group (E1496). Cancer 122:2996-3004

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