Abstract

The Northern California Oncology Group has been formed within the Northern California Cancer Program region to conduct clinical research on the treatment of cancer.
Its aims are to improve the survival and palliation of cancer patients in the northern California and western Nevada regions and in the nation. Utilizing the expertise of its member medical oncologists, radiotherapists, surgeons, pathologists and radiologists and the facilities of its member institutions; phase I, phase II, and phase III clinical trials of anticancer agents and combinations of treatments are evaluated. The Group consists of all of the university hospitals in the region, the military hospitals the large Kaiser HMO organization, large private hospitals and twelve community outreach programs. Major areas of clinical research include the investigation of heavy charged particles and hyperthermia in radiotherapy and the investigation of new drugs and combinations of drugs alone, with radiation and with surgery. The modality oriented approach emphasizes radiation, drug development and biologic response modifiers while the site approach focuses on brain, head and neck, breast, lung, gastrointestinal, genitourinary and gynecologic malignancies. This application is for support for the headquarters operation, the statistical center and two unfunded members.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA021744-07
Application #
3556637
Study Section
Cancer Regional Studies Review Committee (CRS)
Project Start
1977-07-01
Project End
1988-07-31
Budget Start
1985-08-01
Budget End
1988-07-31
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Northern California Cancer Center
Department
Type
DUNS #
City
Fremont
State
CA
Country
United States
Zip Code
94538

  Publications

Sneed, P K; Stauffer, P R; McDermott, M W et al. (1998) Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost +/- hyperthermia for glioblastoma multiforme. Int J Radiat Oncol Biol Phys 40:287-95
Sneed, P K; Lamborn, K R; Larson, D A et al. (1996) Demonstration of brachytherapy boost dose-response relationships in glioblastoma multiforme. Int J Radiat Oncol Biol Phys 35:37-44
Sneed, P K; Prados, M D; McDermott, M W et al. (1995) Large effect of age on the survival of patients with glioblastoma treated with radiotherapy and brachytherapy boost. Neurosurgery 36:898-903;discussion 903-4
Sneed, P K; Gutin, P H; Larson, D A et al. (1994) Patterns of recurrence of glioblastoma multiforme after external irradiation followed by implant boost. Int J Radiat Oncol Biol Phys 29:719-27
Nowakowski, V A; Castro, J R; Petti, P L et al. (1992) Charged particle radiotherapy of paraspinal tumors. Int J Radiat Oncol Biol Phys 22:295-303
MacKenzie, M R; Wold, H; George, C et al. (1992) Consolidation hemibody radiotherapy following induction combination chemotherapy in high-tumor-burden multiple myeloma. J Clin Oncol 10:1769-74
Nowakowski, V A; Ivery, G; Castro, J R et al. (1991) Uveal melanoma: development of metastases after helium ion irradiation. Radiology 178:277-80
Phillips, T L; Levin, V A; Ahn, D K et al. (1991) Evaluation of bromodeoxyuridine in glioblastoma multiforme: a Northern California Cancer Center Phase II study. Int J Radiat Oncol Biol Phys 21:709-14
Petti, P L; Lyman, J T; Castro, J R (1991) Sensitivity of helium beam-modulator design to uncertainties in biological data. Med Phys 18:506-12
Gandara, D R; Valone, F H; Perez, E A et al. (1991) Rapidly alternating radiotherapy and high dose cisplatin chemotherapy in stage IIIB non-small cell lung cancer: results of a phase I/II study. Int J Radiat Oncol Biol Phys 20:1047-52

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