The Southeastern Cancer Study Group grant has supported our clinical investigative activites in the Southeastern Cancer Study Group. The funds have supported our efforst in cooperative clinical trials, investigative surgery, radiation therapy, chemotherapy, immunotherapy, combined-modality treatment in clinical trials for leukemias, lymphomas, lung cancer, melanoma, gastrointestinal cancer, breast cancer, sarcoma, and many other solid tumors. An emphasis has been placed on integrated multi-modality treatment programs in Phase III randomized prospective studies. In addition, we have been actively engaged in pilot studies of new drugs and Phase II trials of new combinations and Phase II non-randomized response studies. We have also developed Phase II and Phase III trials originating inhouse at Vanderbilt. Many of these trials resulted in group protocols after the acquisition of pilot data. We have participated the developing treatment programs for a variety of human neoplasms. In addition to the clinical studies, secondary benefits of excellent patient care and education of medical students, house officers, and oncology fellows are an integral part of the program. A bone marrow transplantation unit has been developed, as well as a clinical pharmacology program; both in cooperation with the SECSG. Continued funding in the area of clinical pharmacology has allowed us to develop relationships with the NIH-funded pharmacology center which is currently very active at Vanderbilt and gives overall strength to our own investigative chemotherapy protocols by providing pharmacologic support for the understanding of the pharmacokinetics of various drugs. Our efforts in clinical pharmacology have provided support for the SECSG. The bone marrow transplantation program has been involved with various group studies. We have an opportunity to study the pharmacology of various drugs given in high doses. We will continue our cooperative efforts in all our activities with the Southeastern Cancer Study Group.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA023909-07
Application #
3556712
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1978-08-01
Project End
1987-07-31
Budget Start
1985-08-01
Budget End
1987-07-31
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37203
Johnson, D H; Bass, D; Einhorn, L H et al. (1993) Combination chemotherapy with or without thoracic radiotherapy in limited-stage small-cell lung cancer: a randomized trial of the Southeastern Cancer Study Group. J Clin Oncol 11:1223-9
Luedke, D W; Einhorn, L; Omura, G A et al. (1990) Randomized comparison of two combination regimens versus minimal chemotherapy in nonsmall-cell lung cancer: a Southeastern Cancer Study Group Trial. J Clin Oncol 8:886-91
Vogler, W R; Raney, M R (1988) Prognostic significance of blood and marrow findings in acute myelogenous leukemia in remission. A Southeastern Cancer Study Group report. Cancer 61:2481-6
Hainsworth, J D; Dial, T W; Greco, F A (1988) Curative combination chemotherapy for patients with advanced poorly differentiated carcinoma of unknown primary site. Am J Clin Oncol 11:138-45
Hainsworth, J D; Johnson, D H; Farese, R V et al. (1987) Limited stage small cell lung cancer: analysis of clinical prognostic factors. South Med J 80:1518-22
Sherry, M M; Greco, F A; Johnson, D H et al. (1986) Metastatic breast cancer confined to the skeletal system. An indolent disease. Am J Med 81:381-6
Kramer, B S; Birch, R; Gockerman, J P et al. (1986) Phase II evaluation of aclarubicin in lung cancer: a Southeastern Cancer Study Group Trial. Cancer Treat Rep 70:803-4
Hainsworth, J D; Porter 3rd, L L; Johnson, D H et al. (1986) Combination chemotherapy with vindesine, etoposide, and cisplatin in non-small cell lung cancer: a pilot study of the Southeastern Cancer Study Group. Cancer Treat Rep 70:339-41
Kramer, B S; Birch, R; Greco, A et al. (1986) Phase II evaluation of acivicin in lung cancer: a Southeastern Cancer Study Group Trial. Cancer Treat Rep 70:1031-2
Sherry, M M; Greco, F A; Johnson, D H et al. (1986) Breast cancer with skeletal metastases at initial diagnosis. Distinctive clinical characteristics and favorable prognosis. Cancer 58:178-82

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