Abstract

Independently and not as an agent of the Government, the Contractor shall exert his best efforts to conduct studies and to carry out clinically indicated modes of therapy as these involve patients with gastric and pancreatic carcinoma. Each patient shall have a microscopically confirmed diagnosis of gastric or pancreatic carcinoma, and whose primary neoplasm has been staged and further characterized according to histological type.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA034184-04
Application #
3557375
Study Section
(NSS)
Project Start
1982-08-01
Project End
1987-01-31
Budget Start
1985-02-01
Budget End
1987-01-31
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
City
Buffalo
State
NY
Country
United States
Zip Code
14263

  Publications

Fleming, R A; Evans, W E; Arbuck, S G et al. (1992) Factors affecting in vitro protein binding of etoposide in humans. J Pharm Sci 81:259-64
Stewart, C F; Arbuck, S G; Fleming, R A et al. (1991) Relation of systemic exposure to unbound etoposide and hematologic toxicity. Clin Pharmacol Ther 50:385-93
Seydel, H G; Stablein, D M; Leichman, L P et al. (1990) Hyperfractionated radiation and chemotherapy for unresectable localized adenocarcinoma of the pancreas. The Gastrointestinal Tumor Study Group experience. Cancer 65:1478-82
Stewart, C F; Fleming, R A; Arbuck, S G et al. (1990) Prospective evaluation of a model for predicting etoposide plasma protein binding in cancer patients. Cancer Res 50:6854-6
Stewart, C F; Arbuck, S G; Fleming, R A et al. (1990) Changes in the clearance of total and unbound etoposide in patients with liver dysfunction. J Clin Oncol 8:1874-9
Stewart, C F; Pieper, J A; Arbuck, S G et al. (1989) Altered protein binding of etoposide in patients with cancer. Clin Pharmacol Ther 45:49-55
(1989) Ifosfamide is an inactive substance in the treatment of pancreatic carcinoma. The Gastrointestinal Tumor Study Group. Cancer 64:2010-3
(1988) Treatment of locally unresectable carcinoma of the pancreas: comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. Gastrointestinal Tumor Study Group. J Natl Cancer Inst 80:751-5
Douglass Jr, H O; Stablein, D M; Thomas, P R (1988) An organized multi-institutional interdisciplinary evaluation of role of radiation therapy alone or combined with chemotherapy in treatment of adenocarcinoma of the gastrointestinal tract. NCI Monogr :253-7
Petrelli, N J; Rustum, Y M; Bruckner, H et al. (1988) The Roswell Park Memorial Institute and Gastrointestinal Tumor Study Group phase III experience with the modulation of 5-fluorouracil by leucovorin in metastatic colorectal adenocarcinoma. Adv Exp Med Biol 244:143-55

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