The long-term objective of the Pediatric Division of the University of Texas M.D. Anderson Cancer Center (UTMDACC) and our Anderson Pediatric Cancer Network of six Texas-based affiliates is to provide comprehensive care to children with cancer and related conditions and to understand better the nature of the diseases - their etiology, eradication, and prevention.
The Specific Aims are (1) to provide the best possible multidisciplinary care to children with cancer, (2) to conduct clinical and basic research in pediatric oncology, (3) to provide specialized clinics in Houston for children with genetic diseases predisposing to cancer (such as neurofibromatosis) and for long-term survivors of pediatric cancer, (4) to care for children and families with neuropsychological problems caused by cancer and/or its treatment, and (5) to educate health professionals in pediatric oncology. The Anderson Pediatric Cancer Network will accomplish specific aims (1) and (2) by active participation in the clinical and basic research activities of the Childrens Cancer Group (CCG). The multidisciplinary team of the Network is composed of 20 pediatric oncologists, 14 at UTMDACC, two in El Paso, and one each in Austin, Amarillo, Lubbock, and San Antonio. The overall plan is to enter each child with cancer on the appropriate CCG clinical trial and basic research study, whenever possible. Approximately 250 children with newly diagnosed cancer are seen annually by the Anderson Pediatric Cancer Network. Of them, 50 are seen at UTMDACC with leukemia/lymphoma (35 patients) or osteosarcoma (15 patients) and have been entered on institutional protocols y Drs. Pinkel and Jaffe, respectively. Another 100 patients are not entered on therapeutic studies because of foreign residence, consultative referral only, no available protocol, or parental refusal. Thus approximately 100 new children with cancer are potentially available annually for ongoing therapeutic trials of the CCG. We expect to enter 75 patients on CCG therapeutic studies in the first year of this grant (12/93 - through 11/94). This number should further increase in subsequent years.
| Freedman, Tanya S; Sondermann, Holger; Friedland, Gregory D et al. (2006) A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci U S A 103:16692-7 |
| Seitzman, Robin L; Glover, Dorie A; Meadows, Anna T et al. (2004) Self-concept in adult survivors of childhood acute lymphoblastic leukemia: a cooperative Children's Cancer Group and National Institutes of Health study. Pediatr Blood Cancer 42:230-40 |
| Raney, R B (1997) Hodgkin's disease in childhood: a review. J Pediatr Hematol Oncol 19:502-9 |
