Phase III Specific Aims:
The specific aims of the randomized portion of the CRYO-ROP follow-up study are to address the following questions: I. Are there long-term structural or functional ocular sequelae in eyes with Threshold ROP that are treated with cryotherapy (vs. those that are not treated) that would require re-evaluation of the risk/benefit ratio of recommending cryotherapy? 2. Do the study data suggest that the """"""""threshold"""""""" for cryotherapy should be lowered? Yearly eye examinations will be performed at 7, 8, 9, and 10 years of age in the randomized ROP patients.
The specific aims of the Natural History portion of the CRYO-ROP follow- up study involve only those CRYO-ROP children who did not develop ROP as an infant. Examinations will be performed at 7, 9, and 10 years of age in these study patients and data collection is designed to address the same ocular status question as the Phase III study of randomized patients.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY006363-13
Application #
2430341
Study Section
Vision Research and Training Committee (VSN)
Project Start
1989-06-01
Project End
1999-05-31
Budget Start
1997-06-01
Budget End
1998-05-31
Support Year
13
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Myers, V S; Gidlewski, N; Quinn, G E et al. (1999) Distance and near visual acuity, contrast sensitivity, and visual fields of 10-year-old children. Arch Ophthalmol 117:94-9