This is an application from The Eye Institute, Medical College of Wisconsin, to participate in the Herpetic Eye Disease Study (HEDS). Our qualifications to participate in HEDS are detailed, including documentation of fully eligible patients during the last year and also estimates from additional sources of recruitment. During the twelve (12) months ending February 28, 1987, 48 HEDS-eligible patients were treated by us; thus we expect to enroll during the first year of funding October 1, 1987 - September 30, 1988, a total of 31 patients during nine months of that first year. During the latter nine months of that first year pilot study patients will be enrolled according to the protocol starting January 1, 1988 through June 30, 1988 during which 17 pilot study patients will be enrolled. Project study patients will be enrolled in all categories beginning July 1, 1988 through September 30, 1988. During those three months 14 project study patients will be enrolled. Forty-five (45) project study patients will be enrolled for the 12 months of the second year of the study - October 1, 1988 - September 30, 1989. The detailed HEDS research plan and operations manual is submitted with the University of California at San Francisco Lead Application. The primary goal of the HEDS is to determine clinical guidelines for the rational use of oral acyclovir (ACV) in herpetic eye infections utilizing a set of clinical trials conducted at major centers in ocular infectious disease. The protocols will determine how ACV affects the progression, the severity, and the rate of recurrence of ocular herpetic infection which is the most common cause of corneal blindness in the United States and other industrialized countries.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY007496-03
Application #
3559584
Study Section
Vision Research and Training Committee (VSN)
Project Start
1988-08-01
Project End
1993-07-31
Budget Start
1990-08-01
Budget End
1991-07-31
Support Year
3
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Wilhelmus, Kirk R; Mitchell, Bradley M; Jones, Dan B et al. (2011) Photographic monitoring of herpes simplex virus keratitis during anti-inflammatory treatment. Arch Ophthalmol 129:252-3
Wilhelmus, Kirk R; Mitchell, Bradley M; Dawson, Chandler R et al. (2009) Slitlamp biomicroscopy and photographic image analysis of herpes simplex virus stromal keratitis. Arch Ophthalmol 127:161-6