The Complications of Age-related Macular Degeneration Prevention Trial (CAPT) is a multi-centered, randomized, controlled clinical trial to evaluate light laser photocoagulation as a preventative treatment for the advanced complications of age-related macular degeneration (AMD) in patients with large drusen in each eyes. The Coordinating Center will provide expertise on study design, statistical analysis, data processing and management, and will coordinate the activities of the study group needed to carry out the study.
The specific aims of the Coordinating Center to fulfill this role are: . Work with the other members of the study group to further refine the study design; . Provide the infrastructure necessary to support the conduct and monitoring of the study; . Create and maintain the study database through design of data collection forms, data collection and processing, and data editing; . Provide timely, regular reports to the clinical centers, CAPT Reading Center; and CAPT Data and Safety Monitoring Committee concerning study progress and performance; . Provide interim and final statistical analysis of the accumulated data; . Design and implement a full program of quality assurance activities; . Design and implement studies of quality of life assessment; . Assist with the preparation of scientific reports.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
3U10EY012279-08S1
Application #
7235464
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Kurinij, Natalie
Project Start
1998-12-07
Project End
2007-11-30
Budget Start
2005-12-01
Budget End
2007-11-30
Support Year
8
Fiscal Year
2006
Total Cost
$351,106
Indirect Cost
Name
University of Pennsylvania
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Rahimy, Ehsan; Ying, Gui-Shuang; Pan, Wei et al. (2018) EFFECT OF INTRAOCULAR PRESSURE-LOWERING MEDICATIONS ON NEOVASCULAR AGE-RELATED MACULAR DEGENERATION TREATMENT OUTCOMES IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENT TRIALS. Retina :
Brader, Hilary Smolen; Ying, Gui-Shuang; Martin, E Revell et al. (2013) Characteristics of incident geographic atrophy in the complications of age-related macular degeneration prevention trial. Ophthalmology 120:1871-9
Sobrin, Lucia; Ripke, Stephan; Yu, Yi et al. (2012) Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. Ophthalmology 119:1874-85
Wolkow, Natalie; Song, Ying; Wu, Ting-Di et al. (2011) Aceruloplasminemia: retinal histopathologic manifestations and iron-mediated melanosome degradation. Arch Ophthalmol 129:1466-74
Brader, Hilary Smolen; Ying, Gui-Shuang; Martin, E Revell et al. (2011) New grading criteria allow for earlier detection of geographic atrophy in clinical trials. Invest Ophthalmol Vis Sci 52:9218-25
Ying, Gui-Shuang; Maguire, Maureen G; Complications of Age-related Macular Degeneration Prevention Trial Research Group (2011) Development of a risk score for geographic atrophy in complications of the age-related macular degeneration prevention trial. Ophthalmology 118:332-8
Ying, Gui-shuang; Maguire, Maureen G; Alexander, Judith et al. (2009) Description of the Age-Related Eye Disease Study 9-step severity scale applied to participants in the Complications of Age-related Macular Degeneration Prevention Trial. Arch Ophthalmol 127:1147-51
Maguire, Maureen G; Ying, Gui-shuang; McCannel, Colin A et al. (2009) Statin use and the incidence of advanced age-related macular degeneration in the Complications of Age-related Macular Degeneration Prevention Trial. Ophthalmology 116:2381-5
Ying, Gui-Shuang; Maguire, Maureen G; Liu, Chengcheng et al. (2008) Night vision symptoms and progression of age-related macular degeneration in the Complications of Age-related Macular Degeneration Prevention Trial. Ophthalmology 115:1876-82
Complications of Age-related Macular Degeneration Prevention Trial (CAPT) Research Group (2008) Risk factors for choroidal neovascularization and geographic atrophy in the complications of age-related macular degeneration prevention trial. Ophthalmology 115:1474-9, 1479.e1-6

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