Retinopathy of prematurity (ROP) is a potentially blinding disease of premature infants in which retinal blood vessels fail to develop properly. A multicentered clinical trial (CRYO-ROP Study) sponsored by the National Eye Institute demonstrated that peripheral retinal ablation at a defined stage of the disease reduced the risk of unfavorable structural outcome (i.e., retinal detachment); however, over 47.1 percent of treated eyes had vision greater than 20/200 at 5 1/2 years. The CRYO-ROP Study also defined a number of risk factors for unfavorable visual and structural outcome in ROP. Despite these advances, ROP remains a leading cause of blindness in children. More effective treatment is required in order to further reduce the rate of blindness. It is hypothesized that earlier treatment of ROP will improve the visual and structural outcome in infants with ROP. Peripheral retinal ablation will be administered to infants who develop prethreshold ROP (ROP that is severe, but not as advanced as threshold ROP as defined by the CRYO-ROP Study). To minimize the risk of treating eyes unnecessarily, since ROP may regress spontaneously in some cases, we will apply a risk management analysis program (RM-ROP2) to eyes with prethreshold disease and enroll infants with a 15 percent or greater risk of an unfavorable structural outcome for treatment. The RM-ROP2 utilizes a number of risk factors to calculate the probability of an eye having an unfavorable structural outcome. Prethreshold infants with a 15 percent or higher risk of an unfavorable outcome will be randomized. One eye will receive earlier treatment and the other will receive conventionally-timed treatment, as defined by the CRYO-ROP Study if required. Outcome will be determined at a 6 month post-term ophthalmologic examination and at a 9 month post-term visual assessment examination.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY012472-09
Application #
7277196
Study Section
Special Emphasis Panel (ZEY1-VSN (06))
Program Officer
Redford, Maryann
Project Start
1999-09-30
Project End
2009-09-29
Budget Start
2007-09-30
Budget End
2008-09-29
Support Year
9
Fiscal Year
2007
Total Cost
$205,088
Indirect Cost
Name
Smith-Kettlewell Eye Research Institute
Department
Type
DUNS #
073121105
City
San Francisco
State
CA
Country
United States
Zip Code
94115
Byun, Jinyoung; Lai, Dejian; Luo, Sheng et al. (2013) A hybrid method in combining treatment effects from matched and unmatched studies. Stat Med 32:4924-37
Davitt, Bradley V; Christiansen, Stephen P; Hardy, Robert J et al. (2013) Incidence of cataract development by 6 months' corrected age in the Early Treatment for Retinopathy of Prematurity study. J AAPOS 17:49-53
Quinn, Graham E; Dobson, Velma; Davitt, Bradley V et al. (2013) Progression of myopia and high myopia in the Early Treatment for Retinopathy of Prematurity study: findings at 4 to 6 years of age. J AAPOS 17:124-8
Siatkowski, R Michael; Good, William V; Summers, C Gail et al. (2013) Clinical characteristics of children with severe visual impairment but favorable retinal structural outcomes from the Early Treatment for Retinopathy of Prematurity (ETROP) study. J AAPOS 17:129-34
Wallace, David K; Bremer, Don L; Good, William V et al. (2012) Correlation of recognition visual acuity with posterior retinal structure in advanced retinopathy of prematurity. Arch Ophthalmol 130:1512-6
Good, William V; Hardy, Robert J; Wallace, David K et al. (2012) ?-Blocking and racial variation in the severity of retinopathy of prematurity. Arch Ophthalmol 130:117-8
Bremer, Don L; Rogers, David L; Good, William V et al. (2012) Glaucoma in the Early Treatment for Retinopathy of Prematurity (ETROP) study. J AAPOS 16:449-52
VanderVeen, Deborah K; Bremer, Don L; Fellows, Rae R et al. (2011) Prevalence and course of strabismus through age 6 years in participants of the Early Treatment for Retinopathy of Prematurity randomized trial. J AAPOS 15:536-40
Wheeler, David T; Dobson, Velma; Chiang, Michael F et al. (2011) Retinopathy of prematurity in infants weighing less than 500 grams at birth enrolled in the early treatment for retinopathy of prematurity study. Ophthalmology 118:1145-51
Repka, Michael X; Tung, Betty; Good, William V et al. (2011) Outcome of eyes developing retinal detachment during the Early Treatment for Retinopathy of Prematurity study. Arch Ophthalmol 129:1175-9

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