The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Corneal Topography Reading Center (CTRC) provides data collection, quality control, storage, database generation and data analysis of corneal topography acquired during the CLEK Study. Corneal topography measurements are an ever increasingly important tool for the detection, diagnosis and long term management of keratoconus. Characterizing the longitudinal changes in corneal curvature is a major CLEK Study outcome variable. This proposal provides documentation and the rationale for establishing the CTRC to incorporate this valuable data set into the overall CLEK analysis picture. The CLEK Study elected, at the outset, to collect corneal topography data on all CLEK Study subjects, and elected not to establish or budget for a reading center or a set of specific aims to analyze these data due to concerns about the accuracy, precision, and interpretation of the curvature data produced. This proposal addresses each of these areas and provides the rationale for analyzing the growing data set. This proposal seeks support for a period of five years to provide for salaries, equipment, computer programming support, consultants, supplies and travel.

National Institute of Health (NIH)
National Eye Institute (NEI)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Special Emphasis Panel (ZEY1-VSN (04))
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University of Illinois at Chicago
Schools of Medicine
United States
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Godefrooij, D A; de Wit, G A; Mangen, M J et al. (2016) Comment on 'Cost effectiveness of collagen crosslinking for progressive keratoconus in the UK NHS'. Eye (Lond) 30:1150-2
Jones-Jordan, Lisa A; Walline, Jeffrey J; Sinnott, Loraine T et al. (2013) Asymmetry in keratoconus and vision-related quality of life. Cornea 32:267-72
Fink, Barbara A; Sinnott, Loraine T; Wagner, Heidi et al. (2010) The influence of gender and hormone status on the severity and progression of keratoconus. Cornea 29:65-72
Kymes, Steven M; Walline, Jeffrey J; Zadnik, Karla et al. (2008) Changes in the quality-of-life of people with keratoconus. Am J Ophthalmol 145:611-617
Mahmoud, Ashraf M; Roberts, Cynthia J; Lembach, Richard G et al. (2008) CLMI: the cone location and magnitude index. Cornea 27:480-7
Szczotka-Flynn, L; Slaughter, M; McMahon, T et al. (2008) Disease severity and family history in keratoconus. Br J Ophthalmol 92:1108-11
Wagner, H; Barr, J T; Zadnik, K (2007) Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study: methods and findings to date. Cont Lens Anterior Eye 30:223-32
McMahon, Timothy T; Edrington, Timothy B; Szczotka-Flynn, Loretta et al. (2006) Longitudinal changes in corneal curvature in keratoconus. Cornea 25:296-305
Davis, Larry J; Schechtman, Kenneth B; Wilson, Brad S et al. (2006) Longitudinal changes in visual acuity in keratoconus. Invest Ophthalmol Vis Sci 47:489-500
Barr, Joseph T; Wilson, Brad S; Gordon, Mae O et al. (2006) Estimation of the incidence and factors predictive of corneal scarring in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study. Cornea 25:16-25

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