Prenatal substance exposure continues to be a major public health problem that affects millions of children and places enormous financial and social burdens on society. The Maternal Lifestyle Study (MLS) is an interagency collaboration involving the National Institute of Child Health and Human Development, the National Institute on Drug Abuse, the Administration on Children, Youth and Families, and the Center for Substance Abuse Treatment. MLS is being conducted in four University sites: Miami, Tennessee at Memphis, Wayne State, and Brown; and it is the largest clinical prospective longitudinal study to date of prenatal drug exposure and child outcome. The follow-up cohort includes 658 exposed and 730 comparison children who have been studied through 7 years of age with 71% retention. This application is to continue the follow-up through age 11.
One aim i s to study the effects of prenatal cocaine/opiate exposure on immediate child outcomes that start in infancy (e.g. attention, relationship to parent, neuromotor, physiologic reactivity, arousal/regulation, and medical status) as well as latent effects on domains of function that emerge later and become salient as children reach school age (e.g. cognition, antisocial behavior, substance use onset, psychopathology, neuroendocrine function, and health disorders). This includes determining the effects of heavy cocaine exposure and controlling for exposure to other drugs (alcohol, marijuana, and tobacco), medical (e.g. physical growth) and environmental factors, gender, minority status, and study site.
The second aim i s to study a broader conceptualization of the consequences of maternal drug use that includes determining how drug effects, and the effects of the postnatal environment combine to affect child outcome, including specific aspects of the environment unique to the drug culture. As a major longitudinal study, MLS is important to the field of developmental science by contributing to our understanding of developmental processes in normal and at-risk children. MLS will also contribute to the field by addressing health indicators related to Healthy People 2010. Understanding the consequences of prenatal cocaine exposure and risky environments is crucial for treatment and public policy. ? ? ?

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Special Emphasis Panel (ZHD1-DSR-H (03))
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Higgins, Rosemary
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University of Tennessee Health Science Center
Schools of Medicine
United States
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Locke, Robin L; Lagasse, Linda L; Seifer, Ronald et al. (2016) Effects of prenatal substance exposure on infant temperament vary by context. Dev Psychopathol 28:309-26
Conradt, Elisabeth; Degarmo, David; Fisher, Phil et al. (2014) The contributions of early adverse experiences and trajectories of respiratory sinus arrhythmia on the development of neurobehavioral disinhibition among children with prenatal substance exposure. Dev Psychopathol 26:901-16
Lambert, Brittany L; Bann, Carla M; Bauer, Charles R et al. (2013) Risk-taking behavior among adolescents with prenatal drug exposure and extrauterine environmental adversity. J Dev Behav Pediatr 34:669-79
Bada, Henrietta S; Bann, Carla M; Whitaker, Toni M et al. (2012) Protective factors can mitigate behavior problems after prenatal cocaine and other drug exposures. Pediatrics 130:e1479-88
Levine, Todd P; Lester, Barry; Lagasse, Linda et al. (2012) Psychopathology and special education enrollment in children with prenatal cocaine exposure. J Dev Behav Pediatr 33:377-86
Bauer, Charles R; Lambert, Brittany L; Bann, Carla M et al. (2011) Long-term impact of maternal substance use during pregnancy and extrauterine environmental adversity: stress hormone levels of preadolescent children. Pediatr Res 70:213-9
Bada, Henrietta S; Bann, Carla M; Bauer, Charles R et al. (2011) Preadolescent behavior problems after prenatal cocaine exposure: Relationship between teacher and caretaker ratings (Maternal Lifestyle Study). Neurotoxicol Teratol 33:78-87
Whitaker, Toni M; Bada, Henrietta S; Bann, Carla M et al. (2011) Serial pediatric symptom checklist screening in children with prenatal drug exposure. J Dev Behav Pediatr 32:206-15
Shankaran, S; Bann, C; Das, A et al. (2011) Risk for obesity in adolescence starts in early childhood. J Perinatol 31:711-6
Shankaran, Seetha; Das, Abhik; Bauer, Charles R et al. (2011) Prenatal cocaine exposure and small-for-gestational-age status: effects on growth at 6 years of age. Neurotoxicol Teratol 33:575-81

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