? ? This proposal addresses two major needs of Pediatric Intensive Care. A). PICUs need a reliable, rapid, and quantitative assessment of functional status for large morbidity studies. Current methods are too time consuming and/or not applicable to infants and young children.
Aim 1 is to validate a rapid and reliable measure of functional status applicable to all PICU ages and suitable for large morbidity studies. The Functional Disability Scale (FDS), a new assessment tool (10 domains with 42 objective, quantitative, easily & rapidly assessed items) has excellent pilot data. The FDS will be validated against the Vineland Adaptive Behavior Scale (VABS) and revised to better represent the relative severity of the individual items Linear regression analysis will utilize 364 patients for estimation and 121 for validation. Classification matrices will be used to choose a cutpoint for low functional status for use in Aim 2. 200 of these patients will have 6-month and 12-month telephone follow-up for FDS determination, enabling us to examine the relationship between hospital discharge status and 6 and 12 month status. B) PICUS have excellent severity measures calibrated to mortality, but there have been no serious efforts to relate ICU physiologi instability to morbidity development.
Aim 2 is to develop a predictor of 3 PICU outcome states: death, survival with low functional status, and survival with adequate functional status. This will enable long-term functional status studies and costs, new quality assessments methods, and improved risk adjustment. Pilot data is very encouraging. This method would be a paradigm shift in severity of illness studies. Trichotomous logistic regression analysis will be used to develop the predictor (3800 for estimation, 1267 for validation). Independent variables include PRISM III, diagnoses, and other case-mix variables. Performance assessment will include overall performance assessment, AUC's, goodness-of-fit, and classification matrices. ? ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD049981-04
Application #
7355599
Study Section
Special Emphasis Panel (ZHD1-DSR-A (04))
Program Officer
Nicholson, Carol E
Project Start
2005-05-01
Project End
2009-11-30
Budget Start
2007-12-01
Budget End
2008-11-30
Support Year
4
Fiscal Year
2008
Total Cost
$435,400
Indirect Cost
Name
Children's Research Institute
Department
Type
DUNS #
143983562
City
Washington
State
DC
Country
United States
Zip Code
20010
Pollack, Murray M; Holubkov, Richard; Reeder, Ron et al. (2018) PICU Length of Stay: Factors Associated With Bed Utilization and Development of a Benchmarking Model. Pediatr Crit Care Med 19:196-203
Pollack, Murray M; Holubkov, Richard; Berg, Robert A et al. (2018) Predicting cardiac arrests in pediatric intensive care units. Resuscitation 133:25-32
Cashen, Katherine; Reeder, Ron; Dalton, Heidi J et al. (2018) Acquired infection during neonatal and pediatric extracorporeal membrane oxygenation. Perfusion 33:472-482
Berg, Robert A; Sutton, Robert M; Reeder, Ron W et al. (2018) Association Between Diastolic Blood Pressure During Pediatric In-Hospital Cardiopulmonary Resuscitation and Survival. Circulation 137:1784-1795
Meert, Kathleen; Telford, Russell; Holubkov, Richard et al. (2018) Paediatric in-hospital cardiac arrest: Factors associated with survival and neurobehavioural outcome one year later. Resuscitation 124:96-105
Cashen, Katherine; Reeder, Ron W; Shanti, Christina et al. (2018) Is therapeutic hypothermia during neonatal extracorporeal membrane oxygenation associated with intracranial hemorrhage? Perfusion 33:354-362
Slomine, Beth S; Silverstein, Faye S; Christensen, James R et al. (2018) Neurobehavioural outcomes in children after In-Hospital cardiac arrest. Resuscitation 124:80-89
Meert, Kathleen; Slomine, Beth S; Christensen, James R et al. (2018) Burden of caregiving after a child's in-hospital cardiac arrest. Resuscitation 127:44-50
Muszynski, Jennifer A; Reeder, Ron W; Hall, Mark W et al. (2018) RBC Transfusion Practice in Pediatric Extracorporeal Membrane Oxygenation Support. Crit Care Med 46:e552-e559
Dalton, Heidi J; Cashen, Katherine; Reeder, Ron W et al. (2018) Hemolysis During Pediatric Extracorporeal Membrane Oxygenation: Associations With Circuitry, Complications, and Mortality. Pediatr Crit Care Med 19:1067-1076

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