Despite decades of research, therapeutic discoveries, and technical innovations, the preterm birth rate continues to rise, particularly in nulliparous women. Researchers have sought to identify genes and genetic variants which are risk factors for preterm birth. However, these studies have been hampered by several limitations, including small sample size, reducing the power to detect association, as well as a heterogeneous population that was not limited to nulliparous women. Given the cost and scope of the problem of preterm birth, utilizing new genomic and proteomic technologies to dissect the etiology of preterm birth is imperative. The long-term research goal is to identify a series of DNA polymorphisms and physiologic biomarkers that will improve the understanding of the disease and will identify the subset of nulliparous women at greatest risk for early preterm birth which would allow for targeted intervention or the institution of preventive measures and strategies for this high-risk group. The objective of this application is to join a network of centers dedicated to collecting specimens and information from pregnant nulliparous women. It is expected that a large biorepository will allow for sufficient volume of specimens to test genetic and biomarker hypotheses rigorously, allowing for the discovery of a unique set of genes and biomarkers to serve as diagnostic and treatment targets. The research proposed will conduct a Genomewide association study (GWAS) for the outcome of preterm birth to identify a set of genetic variants associated with preterm birth. In addition, a gene-environment interaction analysis will be performed to control for important environmental influences known to be associated with preterm birth. This proposal is novel in that no prior GWAS has been reported for preterm birth in nulliparous women. Additionally, prior single gene association studies have not controlled for potentially confounding environmental factors in a large, well characterized sample. The research is significant in that preterm birth leads to considerable neonatal morbidity, mortality, and health care costs. It is imperative to develop new strategies to understand this and other pregnancy complications to better prevent, diagnose, and treat conditions such as preterm birth.

Public Health Relevance

The proposal is relevant to public health because it uses novel technologies to better understand the mechanism of disease forthis escalating pregnancy complication which impacts both families and society. The research results from this network of biobanks has potential to dramatically improve providers'ability to prevent, diagnose, and treat many complications of pregnancy in addition to preterm birth.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD063037-04
Application #
8605888
Study Section
Special Emphasis Panel (ZHD1-DSR-K (29))
Program Officer
Higgins, Rosemary
Project Start
2010-01-10
Project End
2014-12-31
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
4
Fiscal Year
2014
Total Cost
$182,521
Indirect Cost
$65,520
Name
Indiana University-Purdue University at Indianapolis
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Haas, David M; Marsh, Derek J; Dang, Danny T et al. (2018) Prescription and Other Medication Use in Pregnancy. Obstet Gynecol 131:789-798
Louis, Judette M; Koch, Matthew A; Reddy, Uma M et al. (2018) Predictors of sleep-disordered breathing in pregnancy. Am J Obstet Gynecol 218:521.e1-521.e12
Facco, Francesca L; Grobman, William A; Reid, Kathryn J et al. (2017) Objectively measured short sleep duration and later sleep midpoint in pregnancy are associated with a higher risk of gestational diabetes. Am J Obstet Gynecol 217:447.e1-447.e13
Reid, Kathryn J; Facco, Francesca L; Grobman, William A et al. (2017) Sleep During Pregnancy: The nuMoM2b Pregnancy and Sleep Duration and Continuity Study. Sleep 40:
Esplin, M Sean; Elovitz, Michal A; Iams, Jay D et al. (2017) Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women. JAMA 317:1047-1056
Parry, Samuel; Sciscione, Anthony; Haas, David M et al. (2017) Role of early second-trimester uterine artery Doppler screening to predict small-for-gestational-age babies in nulliparous women. Am J Obstet Gynecol 217:594.e1-594.e10
Facco, Francesca L; Parker, Corette B; Reddy, Uma M et al. (2017) Association Between Sleep-Disordered Breathing and Hypertensive Disorders of Pregnancy and Gestational Diabetes Mellitus. Obstet Gynecol 129:31-41
Bodnar, Lisa M; Simhan, Hyagriv N; Parker, Corette B et al. (2017) Racial or Ethnic and Socioeconomic Inequalities in Adherence to National Dietary Guidance in a Large Cohort of US Pregnant Women. J Acad Nutr Diet 117:867-877.e3
Bann, Carla M; Parker, Corette B; Grobman, William A et al. (2017) Psychometric properties of stress and anxiety measures among nulliparous women. J Psychosom Obstet Gynaecol 38:53-62
Hoffman, Matthew K; Turan, Ozhan M; Parker, Corette B et al. (2016) Ultrasound Measurement of the Fetal Adrenal Gland as a Predictor of Spontaneous Preterm Birth. Obstet Gynecol 127:726-34

Showing the most recent 10 out of 13 publications