The University of Pennsylvania Health System's Department of Obstetrics and Gynecology reflects a long tradition of excellence in clinical and translational research. Investigators within the Division of Maternal-Fetal Medicine have been key participants in this tradition, particularly in their studies of genetic factors and environmental exposures that are associated with preterm birth. In this application, we provide information on the two hospitals that comprise the obstetric services at the University of Pennsylvania - the Hospital of the University of Pennsylvania (HUP) and Pennsylvania Hospital (PAH) - both of which are proposed sites of patient recruitment for the network.
The specific aims of this application are: 1) to provide consultation on the design of network studies, which includes assisting the Steering Committee in study design, sample size calculations, and statistical analyses, and selecting optimal data and sample collection protocols;2) to enroll subjects into network studies and to provide quality data for network studies;3) to perform ultrasound studies, laboratory assays, and high-throughput genomics and proteomics assays required to complete proposed studies;and 4) to be involved in the analysis and publication of network studies. The combined delivery volume of HUP and PAH is over 9,000 per year. The MFM physicians at the two hospitals share clinical responsibilities and have a substantial track record for collaboration in various clinical studies. Importantly, the principal investigator for this application is the principal investigator of the Analytical Core for the Genomics and Proteomics Network for Preterm Birth Research and will bring significant expertise regarding study design, sample collection, and assay techniques (including high-throughput studies), to the proposed preterm birth network. The investigators propose a prospective cohort study in which prenatal ultrasound findings (cervical length, uterine artery Doppler flow), protein biomarkers (circulating angiogenic factors, proteomics techniques using labeled proteins from cells of interest), and transcriptomics assays will be correlated with clinical outcomes and placental histology findings. The hypothesis to be tested is that markers of placental dysfunction early in pregnancy will identify nulliparous women at risk of preterm birth.

Public Health Relevance

Preterm birth affects 12 percent of all pregnancies in the U.S., and complications from preterm delivery are the second leading cause of neonatal mortality. Nulliparous women are an under-studied population, particularly concerning their risk of preterm birth. The proposed network to study preterm birth in nulliparous women has the opportunity to identify risk factors for preterm birth among these women and develop novel therapeutic strategies to prevent preterm deliveries.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-K (29))
Program Officer
Higgins, Rosemary
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
Obstetrics & Gynecology
Schools of Medicine
United States
Zip Code
Haas, David M; Marsh, Derek J; Dang, Danny T et al. (2018) Prescription and Other Medication Use in Pregnancy. Obstet Gynecol 131:789-798
Louis, Judette M; Koch, Matthew A; Reddy, Uma M et al. (2018) Predictors of sleep-disordered breathing in pregnancy. Am J Obstet Gynecol 218:521.e1-521.e12
Parry, Samuel; Sciscione, Anthony; Haas, David M et al. (2017) Role of early second-trimester uterine artery Doppler screening to predict small-for-gestational-age babies in nulliparous women. Am J Obstet Gynecol 217:594.e1-594.e10
Facco, Francesca L; Parker, Corette B; Reddy, Uma M et al. (2017) Association Between Sleep-Disordered Breathing and Hypertensive Disorders of Pregnancy and Gestational Diabetes Mellitus. Obstet Gynecol 129:31-41
Bodnar, Lisa M; Simhan, Hyagriv N; Parker, Corette B et al. (2017) Racial or Ethnic and Socioeconomic Inequalities in Adherence to National Dietary Guidance in a Large Cohort of US Pregnant Women. J Acad Nutr Diet 117:867-877.e3
Bann, Carla M; Parker, Corette B; Grobman, William A et al. (2017) Psychometric properties of stress and anxiety measures among nulliparous women. J Psychosom Obstet Gynaecol 38:53-62
Facco, Francesca L; Grobman, William A; Reid, Kathryn J et al. (2017) Objectively measured short sleep duration and later sleep midpoint in pregnancy are associated with a higher risk of gestational diabetes. Am J Obstet Gynecol 217:447.e1-447.e13
Reid, Kathryn J; Facco, Francesca L; Grobman, William A et al. (2017) Sleep During Pregnancy: The nuMoM2b Pregnancy and Sleep Duration and Continuity Study. Sleep 40:
Esplin, M Sean; Elovitz, Michal A; Iams, Jay D et al. (2017) Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women. JAMA 317:1047-1056
Hoffman, Matthew K; Turan, Ozhan M; Parker, Corette B et al. (2016) Ultrasound Measurement of the Fetal Adrenal Gland as a Predictor of Spontaneous Preterm Birth. Obstet Gynecol 127:726-34

Showing the most recent 10 out of 13 publications